Between the Lines

John Marshall, MD​, and Mark Lewis, MD​, discuss how circulating tumor DNA (ctDNA) testing in colorectal cancer offers promising clinical utility across the care continuum, from early detection to treatment monitoring, with trials like BESPOKE and SWOG 80702 demonstrating its potential to guide personalized therapy decisions, predict outcomes based on minimal residual disease status, complement traditional imaging in challenging cases, and transform patient care through a patient-centric approach that requires ongoing research to establish standardized protocols.

Experts discuss the analyses on the impact of tumor burden at progression and changes in IMDC risk scores in the CLEAR trial, providing prognostic insights in advanced RCC with lenvatinib plus pembrolizumab.

Experts discuss the 3-year follow-up results from the phase 3 TRANSFORM study, comparing liso-cel with standard of care with salvage chemotherapy followed by autologous stem cell transplant (ASCT) as second-line treatment in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL).

David Ilson, MD, PhD; Sunnie Kim, MD; and Raji Shameem, MD,​ discuss how first-line nivolumab plus chemotherapy has demonstrated sustained survival benefits in advanced gastric cancer, with PD-L1 combined positive scores helping guide patient selection. Long-term safety data support its role as standard of care, particularly benefiting patients with PD-L1–high disease, though unmet needs remain in subgroups with PD-L1–low disease.

Joshua K. Sabari, MD, and Martin Dietrich, MD, PhD, examine both the evolution of first-line EGFR TKIs as standard treatment for EGFR-mutated metastatic non-small cell lung cancer and the ongoing clinical challenges in managing resistance, toxicities, and treatment sequencing in this space.

Panelists discuss how the CLEAR trial highlights the efficacy of lenvatinib plus pembrolizumab over sunitinib in advanced renal cell carcinoma, focusing on patterns of progression and the implications for subsequent therapy.

Panelists discuss how nivolumab plus relatlimab may offer a similar efficacy to nivolumab plus ipilimumab in advanced melanoma, with a potentially better safety profile, based on an indirect treatment comparison using data from the RELATIVITY-047 and CheckMate 067 trials.

Mike J. Pishvaian, MD, PhD; Stacey Cohen, MD; and Mark Lewis, MD, FASCO, discuss how recent advancements in circulating tumor DNA (ctDNA) and minimal residual disease (MRD) testing are revolutionizing colorectal cancer management across the care continuum, from early detection to treatment selection and monitoring, with key insights from major clinical trials like DYNAMIC and GALAXY informing more personalized and effective treatment strategies.

Panelists discuss how the CARTITUDE-4 study data highlights the significant survival benefits of ciltacabtagene autoleucel compared to with standard of care in patients with lenalidomide-refractory multiple myeloma, emphasizing its potential to reshape treatment paradigms in this challenging population.

Panelists discuss managing infusion-related reactions with amivantamab and lazertinib, compare these reactions with those from other treatments, and review SKIPPirr data to provide insights on incorporating prophylactic dexamethasone 8 mg, addressing implementation barriers, and educating patients.

Panelists discuss insights from the MARIPOSA study on first-line treatment options for EGFR-mutant metastatic non–small cell lung cancer (NSCLC), highlighting the efficacy of amivantamab-lazertinib over osimertinib, the importance of managing adverse events, adherence to National Comprehensive Cancer Network guidelines, and the need for patient engagement in treatment discussions to address unmet needs.

Panelists discuss how myelofibrosis management involves a blend of medications, supportive care, and potential stem cell transplantation, with a focus on Janus kinase inhibitors and investigational agents like pelabresib for modifying disease progression, as well as the findings from the MANIFEST-2 trial regarding spleen volume reduction and biomarker data.

Larysa Sanchez, MD; and Samantha Shenoy, MSN, NP, discuss the management of adverse events with bispecific antibodies like GPRC5D and talquetamab while providing guidance on optimizing treatment outcomes and supportive care, as well as offering advice for managing toxicities and future perspectives on relapsed/refractory multiple myeloma.

Rahul Gosain, MD; Rohit Gosain, MD, and Daniel Ahn, DO, analyze pivotal studies in hepatocellular carcinoma, including HIMALAYA, IMbrave 150, and CheckMate 9DW, discussing study designs, outcomes, patient characteristics, and efficacy data.

Gastrointestinal medical oncologists review recent clinical research and have a comprehensive discussion on the use of circulating tumor DNA (ctDNA) as a predictive biomarker in patients with colorectal cancer.

Key opinion leaders examine the current frontline treatment options for mantle cell lymphoma while identifying critical unmet patient needs requiring attention.

Martin H. Voss, MD, and Moshe C. Ornstein, MD, review significant renal cell carcinoma research developments presented at ASCO 2024, highlighting data and insights poised to reshape the disease's treatment landscape.

Hematologic oncology specialists review recent data from the PERSEUS trial analyzing minimal residual disease in patients with newly diagnosed multiple myeloma who receive DARA-VRd.

Amrita Y. Krishnan, MD, and Binod Dhakal, MD, review recent data from the MajesTEC-1 trial of teclistamab in patients with relapsed/refractory multiple myeloma and have a discussion on evolving therapeutic practices.

Expert perspectives on the phase III MARIPOSA-2 trial results evaluating amivantamab-based regimens in EGFR-mutant NSCLC after osimertinib progression. The discussion covers efficacy, safety, clinical implications, and future directions featuring Martin Dietrich, MD; Ticiana Leal, MD, and Sandip P. Patel, MD.

Medical Oncologists Sandip Patel, MD and Helena Yu, MD discuss data from the HERTHENA-Lung01 trial investigating HER3-DXd in EGFR-mutated NSCLC and the evolving treatment landscape in NSCLC.

A panel of experts on multiple myeloma review data from the MonumenTAL-1 clinical trial investigating talquetamab and provide comprehensive insights on treating patients and managing adverse effects.

Marwan G. Fakih, MD, and Atif Hussein, MD, MMM, FACP, review data from the SUNLIGHT study and discuss their impact on the overall treatment landscape in metastatic colorectal cancer.

Expert perspectives on a recent clinical trial readout indirectly comparing acalabrutinib and zanubrutinib in patients with relapsed/refractory chronic lymphocytic leukemia.

Expert hematologist-oncologists review data from the MajesTEC-1 trial and discuss the optimal management of cytokine release syndrome in patients on therapy for relapsed/refractory multiple myeloma.

Key opinion leaders review recent data from the ASCO 2023 annual meeting surrounding the MonumenTAL-1 and RedirecTT-1 trials, considering their impact on the real-world management of relapsed/refractory multiple myeloma.

Toni Choueiri, MD, and Rohit Gosain, MD present 3-year follow-up data from the CheckMate 9ER trial, discussing a variety of outcomes concerning the use of nivolumab plus cabozantinib in patients with advanced renal cell carcinoma, and sharing clinical insights for community oncologists.

Joshua K. Sabari, MD, and Helena A. Yu, MD, discuss the evolving treatment landscape in non–small cell lung cancer for patients with EGFR exon 20 insertion mutations and results from a real-world study that may impact the field.

Nelson J. Chao, MD, MBA, and Michael Grunwald, MD review Acute Graft-Versus-Host Disease diagnosis and treatment before engaging with two REACH2 trial post hoc analyses, sharing clinical implications and key takeaways.