Tivozanib Shows Efficacy in Pretreated Metastatic RCC
There appeared to be no extra benefit with the addition of nivolumab to tivozanib among patients included in the phase 3 TiNivo-2 trial.
Iopofosine I 131 Shows Preliminary Survival Benefit in Pediatric R/R Glioma
The safety profile of iopofosine I 131 in the phase 1b CLOVER-2 trial appears consistent with prior reports of the agent.
Elacestrant Regimens Show Activity in Pretreated ER+/HER2– Breast Cancer
Data from the ELEVATE trial may support elacestrant as an endocrine therapy backbone in ER-positive, HER2-negative metastatic breast cancer.
FDA Approves Taletrectinib in ROS1+ NSCLC
Supporting results for the approval of taletrectinib in ROS1+ NSCLC come from the TRUST-I and TRUST-II trials.
Preoperative Counseling Increases Shared Decision-Making in CRC Surgery
Counseling received prior to colorectal surgery using 3-dimensional–printed anatomic models reduced mean anxiety scores vs conventional counseling.
Robust Responses Occur With UGN-102 in Recurrent Intermediate-Risk NMIBC
Data from the ENVISION trial may support UGN-102 as a well-tolerated, efficacious treatment in non–muscle-invasive bladder cancer.
microRNA-based Signatures Predict irAEs in Patients Receiving Anti-PD1 Treatment
Data from a study shared at the 2025 ASCO Annual Meeting showed that a microRNA-based model was able to predict irAEs in various cancers for those on anti-PD1 therapy.
Frontline Nivolumab Combo Shows Enduring Activity in MSI-H Gastric Cancer
Phase 2 data may support nivolumab plus low-dose ipilimumab as a promising option in patients with microsatellite instability–high gastric cancer.
microRNA-Based Model Predicts SBRT Outcomes in Soft Tissue Sarcomas
Identifying which patients are at risk of distant failure may assist oncologists in deciding who should receive neoadjuvant radiation, according to Joanne B. Weidhaas, MD, PhD, MBM.
China’s CDE Accepts Marketing Application for Pimicotinib in TGCT
In the phase 3 MANEUVER trial, pimicotinib improved the objective response rate vs placebo in patients with tenosynovial giant cell tumor.
Lurbinectedin Maintenance Combo Earns FDA Priority Review in ES-SCLC
The FDA has set a Prescription Drug User Fee Act date of October 7, 2025, for its decision on approving the lurbinectedin combination in this SCLC population.
Epcoritamab Elicited Sustained PFS and OS at 3 Years in R/R LBCL
Epcoritamab monotherapy led to long-term disease-free remissions in patients with relapsed/refractory large B-cell lymphoma who achieved complete response at 2 years.
New microRNA Models Predict Responses and Toxicities in Various Cancers
Joanne B. Weidhaas, MD, PhD, MBM, presented 2 abstracts based on microRNA technology at the 2025 ASCO Annual Meeting that demonstrated predictive power.
FDA Lifts Hold on IFx-2.0 in Advanced/Metastatic Merkel Cell Carcinoma
A phase 3 trial evaluating frontline IFx-2.0 with pembrolizumab in advanced/metastatic Merkel cell carcinoma is planned to start later in June 2025.
Satri-Cel Improves Survival vs Physician’s Choice in Pretreated Gastric/GEJ Cancer
Satri-cel led to a median PFS of 3.25 months vs 1.77 months with physician’s choice in patients with pretreated gastric or gastroesophageal cancer.
Cilta-Cel Demonstrates "Curative Potential" in R/R Multiple Myeloma
The median overall survival with cilta-cel exceeds 5 years among patients with relapsed/refractory multiple myeloma in the CARTITUDE-1 trial.
Sacituzumab Tirumotecan Enhances Efficacy in Pretreated EGFR-Mutant NSCLC
Sacituzumab tirumotecan showed a manageable safety profile compared to docetaxel in patients with EGFR-mutant advanced non–small cell lung cancer.
Fostering a Team-Based Approach to Elevate Neuro-Oncology Care
Specialties including neurosurgery, radiation oncology, and neuro-rehabilitation all play a notable role in the care of patients with brain tumors.
CAR T and Transplantation Advances Across Hematologic Cancers at ASCO 2025
An expert panel highlights key presentations in multiple myeloma, lymphoma, and other hematologic malignancies at the 2025 ASCO Annual Meeting.
Maximizing Quality of Life From the Get-Go in Neuro-Oncology Care
Treatment-related toxicities during neuro-oncology therapy appear well managed with dose modifications and treatment cycle holds.
RP1/Nivolumab Combo Shows Responses in Advanced Pretreated Melanoma
Data from the IGNYTE trial demonstrate the development of a robust systemic antitumor response following treatment with RP1.
Nivolumab May Enhance Outcomes with SOC Therapy for Locally Advanced HNSCC
The phase 3 NIVOSTOP trial evaluated an anti–PD-1 immunotherapy, nivolumab, in a patient population similar in the KEYNOTE-689 trial.
Tracing the Evolution of Immunotherapies in Neuro-Oncology
CAR T-cell therapies appear to be an evolving modality in the treatment of those with intracranial tumors, said Sylvia Kurz, MD, PhD.
Socazolimab Exhibits Overall Survival Benefit Vs Placebo in ES-SCLC
The addition of socazolimab to carboplatin plus etoposide was well tolerated compared with placebo in patients with extensive-stage small cell lung cancer.
KEYNOTE-689 Results Provide “Foundation” for Alternative HNSCC Strategies
Opportunities to further reduce relapses include pembrolizumab-based combination therapy and evaluating the agent’s contribution before and after surgery.
Addition of Pembrolizumab to SOC May Enhance HNSCC Cure Rates
For patients with locally advanced head and neck cancers, the current standard of care for curative therapy has a cure rate of less than 50%.
Patient-Reported Outcome Study is “Critically Important” in Cervical Cancer
According to Maurie Markman, MD, patient-reported outcomes pertain to more relevant questions surrounding the impact of therapy for patients.
Radiopharmaceutical Agent Shows Efficacy, Tolerability in SSTR2+ NETs
Brandon R. Mancini, MD, MBA, FACRO, discussed results from a phase 1/2a trial that evaluated [212Pb]VMT-α-NET in patients with advanced NETs.
Exploring the Rare Lymphoma Landscape
CancerNetwork® spoke with Neha Mehta-Shah, MD, MSCI, about the clinical landscape for patients undergoing treatment for rare lymphomas.
Ibrilatazar Shows Survival Improvement in Advanced Squamous NSCLC
Following the induction phase with chemotherapy alone, ibrilatazar has shown a manageable toxicity profile in patients with advanced squamous NSCLC.