Protecting Sexual Function Via The Hood Technique in Prostate Cancer
“Even after doing 10,000 of these operations, we are tweaking [the hood technique]…to make things better,” according to Ash Tewari, MD, MBBS, MCh, FRCS.
Enfortumab Vedotin Combo Yields ‘Transformative’ Urothelial Cancer Outcomes
Updated findings from the phase 3 EV-302 trial show enduring responses and survival improvements with enfortumab vedotin plus pembrolizumab.
Neoadjuvant Nivolumab/Chemo Improves OS Vs Chemotherapy in Resectable NSCLC
Updated, comprehensive OS results with the combination in resectable NSCLC will be shared in a future peer-reviewed setting.
Zongertinib Receives FDA Priority Review in HER2–Mutant Advanced NSCLC
Efficacy results from cohort 1 of the phase 1b Beamion LUNG-1 trial support the decision to review zongertinib in HER2-mutant advanced NSCLC.
Outlining the Impact of AI on Multidisciplinary Oncology Practice
AI-powered tools may help alleviate doctor burnout and give clinicians more time to directly engage with patients.
3 Things You Should Know About Identifying and Treating Epithelioid Sarcoma
Experts discuss epithelioid sarcoma diagnosis, management, and targeted therapies, and highlight 3 things everyone should know about treatment.
Dordaviprone Earns Priority Review in H3 K27M-Mutant Diffuse Glioma
The FDA has accepted an NDA and set a PDUFA date of August 18, 2025, for the decision on dordaviprone in H3 K27M-mutant diffuse glioma.
Study Finds Recent Falls, Inability to Balance on Left Leg Indicate OS Decrease in NHL
Adverse physical functions were indicative of reduced survival and increased risk of ICANS in patients with non-Hodgkin lymphoma who were previously treated with CAR T-cell therapy.
Newer, Alternative Treatment Methods May Improve Brain Tumor Care
An individualized vaccine as well as aerosolized medicines are 2 novel forms of treatment that are under development for managing brain tumors.
Darolutamide/ADT Yields Consistent Outcomes Across HSPC Age Subgroups
Data show improvements in overall survival and time to subsequent therapy initiation with darolutamide plus ADT/docetaxel.
Advancing the MZL Landscape Through the MZL Workshop
Davide Rossi, MD, spoke about the impact of the MZL workshop and his hopes for the future of treatment and medicine in MZL.
Age Did Not Negatively Impact Response From CAR T-Cell Therapy in R/R LBCL
Median PFS and OS were comparable between age groups when CAR T-cell therapy was given as treatment for patients with relapsed/refractory LBCL.
Belzutifan Receives European Approval in Localized/Advanced RCC Indications
LITESPARK-004 and LITESPARK-005 trial results support the approval of belzutifan in patients with associated localized or advanced clear cell RCC.
Venetoclax/Ibrutinib Significantly Improves PFS in Mantle Cell Lymphoma
The safety profile of ibrutinib/venetoclax in the phase 3 SYMPATICO trial was consistent with the known profiles for each individual agent.
Forecast on Eliminating Cancer Disparities Looks to Ethnic Enclave Research
Scarlett Lin Gomez, MPH, PhD, highlights facts from her research that are impacting cancer disparities and how she is finding ways to improve them.
Ide-Cel Yields High Response Rates in Post-Transplant Myeloma Patients
Idecabtagene vicleucel led to high rates of MRD negativity in multiple myeloma who responded did not have complete responses to first-line therapy.
Promising Trials May Have an Impact in the Brain Tumor Environment
Frances Chow, MD, and Elizabeth Ren Zhang-Velten, MD, PhD, spoke about several facets of the current brain tumor landscape, including targeted therapies.
First-Line Olaparib/Abiraterone Shows Clinical Benefit in BRCA+ mCRPC
Olaparib plus abiraterone improved radiographic PFS and overall survival in mCRPC patients with germline or somatic BRCA mutations vs placebo plus abiraterone.
Regorafenib/Sintilimab Show Tolerability and Mixed Efficacy in MSS mCRC
Efficacy results demonstrated by regorafenib and sintilimab in patients with mSS mCRC were dependent on patient characteristics such location of metastasis and RAS type.
HRQOL Analysis Assess Populations and Treatment Options in Bladder and Prostate Cancer
A team from the University of Munich analyzed HRQOL outcomes in rural/urban patients with bladder cancer and after ADT treatment and postoperative radiotherapy in prostate cancer.
FDA Grants Fast Track Designation to IBI363 in Pretreated Squamous NSCLC
IBI363 demonstrated encouraging efficacy and a manageable safety profile in patients with squamous NSCLC based on results from a phase 1 trial.
Ruxolitinib Plus Standard Prophylaxis Lowers GVHD Risk in Myelofibrosis
Ruxolitinib shows promise in improving transplant outcomes for myelofibrosis patients by reducing GVHD incidence without compromising survival.
Pinpointing Ways to Overcome Challenges in MZL
As MZL is such a rare subtype of lymphoma, it can be hard to find or begin trials geared specifically toward this population.
Highlighting Insights From the Marginal Zone Lymphoma Workshop
Clinicians outline the significance of the MZL Workshop, where a gathering of international experts in the field discussed updates in the disease state.
PROs Comparable with Tivozanib Alone or With Nivolumab in Advanced Clear Cell RCC
The TiNivo-2 trial found comparable PROs with tivozanib plus nivolumab vs tivozanib monotherapy in advanced clear cell RCC.
OPN-6602 Granted Orphan Drug Designation in R/R Multiple Myeloma
Data from a multiple myeloma mouse xenograft model demonstrated promising tumor regression activity from OPN-6602 monotherapy and in combination with standard of care agents.
Hood Technique Improves Earlier Continence in Prostate Cancer Surgery
The hood technique, developed by Ash Tewari, MD, aids in facilitating earlier returns of continence with reduced residual cancer rates.
Nivolumab Combinations Show Best Treatment Options for Advanced Melanoma
Ahmad Tarhini, MD, PhD, and Hussein A. Tawbi, MD, PhD, discussed data from the RELATIVITY-047 and CheckMate 076 trial for patients with melanoma.
Positive Efficacy Noted With Cemiplimab/Chemotherapy in Penile Carcinoma
The phase 2 EPIC trial assessing patients with penile carcinoma met its primary end point of clinical benefit rate, with the lower bound of the confidence interval exceeding the null hypothesis limit.
Durable Responses in Low-Grade, Intermediate-Risk NMIBC with UGN-102
Data from the ENVISION and ATLAS trials demonstrated clinically meaningful responses with UGN-102 in the treatment of low-grade, intermediate-risk NMIBC.