Antibody-Targeted Chemotherapy in Relapsed AML
SEATTLE-Preliminary phase II data show that CMA-676, an engineered human anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent, produced an objective response in 10 of 23 patients (43%) with acute myelogenous leukemia in first relapse after initial chemotherapy. Six responders went on to allogeneic bone marrow transplant.
SEATTLEPreliminary phase II data show that CMA-676, an engineered human anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent, produced an objective response in 10 of 23 patients (43%) with acute myelogenous leukemia in first relapse after initial chemotherapy. Six responders went on to allogeneic bone marrow transplant.
The side effects are mild compared to standard chemotherapy, Eric Sievers, MD, of Fred Hutchinson Cancer Research Center, said at ASH. The antibody was given as a single agent intravenously at a dose of 9 mg/m² every 2 weeks for two doses. The agent, from Wyeth-Ayerst Research (Radnor, PA), is being tested at 13 leading US leukemia centers.
ASH 2024 Preview for Integrative Care: The Show and After Show
December 3rd 2024CancerNetwork co-hosts Kristie L. Kahl and Andrew Svonavec highlight abstracts to look out for surrounding the multidisciplinary approach at the upcoming ASH Annual Meeting in San Diego, with some additional tidbits to round out the main event.
Improving Disease Modification and Immune Responses in Myelofibrosis With Pelabresib
November 16th 2024David M. Swoboda, MD, and Andrew Kuykendall, MD, spoke about the current treatment strategies and potential advancements that may improve outcomes such as spleen volume reduction in the myelofibrosis field.
