Are AIs for Breast Cancer Linked With Increased Myocardial Infarction Risk?
This video examines a study that looked at whether aromatase inhibitors are associated with higher myocardial infarction risk in breast cancer patients.
In this video, Sailaja Kamaraju, MD, of the Medical College of Wisconsin, discusses a study that looked at whether aromatase inhibitors (AIs) are associated with higher myocardial infarction risk in breast cancer patients.
The study looked at 5,648 women (67 years and older) from the Surveillance, Epidemiology, and End Results–Medicare (SEER) database with stages I–III breast cancer who were treated with either AIs (n = 4,690) or tamoxifen (n = 958). With over 2 years follow-up there were 22 deaths from myocardial infarction (251 total cases), with 476 deaths from other causes.
Giredestrant Combo Yields Positive PFS in Subgroups After CDK4/6i in ER+/HER2– Breast Cancer
December 13th 2025“The magnitude of clinical benefit was clinically meaningful and consistent, and was regardless of PIK3CA mutations or alterations in the PIK3CA pathway, duration of prior CDK4/6 inhibitors, including patients who progress within 6 to 12 months, and the choice of prior CDK4/6 inhibitors,” said Hope S. Rugo, MD.
