ASA404 pivotal trial in lung cancer begins
BASEL-Novartis’ ASA404 has entered a phase III lung cancer trial following positive outcomes of a phase II study.
BASEL-Novartis’ ASA404 has entered a phase III lung cancer trial following positive outcomes of a phase II study. ASA404 is a small-molecule tumor-vascular disrupting agent that selectively causes the collapse of existing tumor blood supply leading to extensive tumor cell death. Its action is distinct from that of angiogenesis inhibitors, which inhibit the formation of new tumor blood vessels.
The ATTRACT-1 trial will include 1,200 patients with previously untreated locally advanced or metastatic NSCLC, randomized to carboplatin/paclitaxel plus either ASA404 or placebo.
Neoadjuvant Capecitabine Plus Temozolomide in Atypical Lung NETs
Read about a woman with well-differentiated atypical carcinoid who experienced a 21% regression in primary tumor size after 12 months on neoadjuvant capecitabine and temozolomide.
