Catherin Watson, MD, Assesses the Future of Genetic Testing in Ovarian Cancer

Video

At SGO 2022, Catherine Watson, MD, spoke about how to encourage patients with ovarian cancer to seek genetic testing.

CancerNetwork® spoke with Catherine Watson, MD, an assistant professor of gynecologic oncology at the Vanderbilt University Medical Center, at The Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer about creating larger studies focused on genetic testing for different populations of patients with ovarian cancer.

At the meeting, Watson presented results of a trial showing that streamlined vs traditional education for genetic testing produced similar outcomes and may offer an alternative that broadens its use overall.

Transcript:

A lot of people in the country have already moved to a point of care model just for logistic reasons. It’s easier and they want to get these women tested. This can add a level of comfort knowing that this is safe for patients as well. It’s not having a negative psychological impact on their patients. Larger studies would be helpful. Due to the COVID pandemic, we weren’t able to adequately power this to make it a noninferiority study, so we can say that these outcomes are the same or there’s no difference but it’s not a true noninferiority study.

Reference

Watson C. Prospective, randomized trial of streamlined genetic education and testing for patients with high grade epithelial ovarian, fallopian and peritoneal cancer. Presented at: The Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer; March 18-21, 2022; Phoenix, AZ.

Recent Videos
Oncologists are still working on management strategies for neuropathy; a common adverse effect related to chemotherapeutics for ovarian cancer.
Genetic testing information can be used to risk-stratify ovarian cancer survivors for breast cancer, particularly those with BRCA1 or BRCA2 mutations.
Genetic testing for ovarian cancer may help inform treatment decisions for patients with advanced disease, particularly regarding PARP inhibitor use.
Future findings from a translational analysis of the OVATION-2 trial may corroborate prior clinical data with IMNN-001 in advanced ovarian cancer.
Approximately 10% of patients discontinued treatment with avutometinib/defactinib due to toxicity in the phase 2 RAMP 201 trial.
Response rates appeared to be higher with avutometinib plus defactinib vs avutometinib alone in the phase 2 RAMP 201 study.
Patients who respond to avutometinib/defactinib may be maintained on treatment for long periods of time, says Rachel N. Grisham, MD.
Findings from the OVARIO study show that patients with HRR–deficient and BRCA-mutated disease benefitted the most from niraparib/bevacizumab maintenance.