Gene Therapy for Liver Cancer
Rockville, Md --GenVec has begun a phase I study of its in vivo gene-based product, AdgvCD. 10, in 18 patients with liver metastases of colectoral cancer . An advenovirus vector modified to carry the cytosine deaminase gene will be administered directly into the hepatic tumor. The gene expresses an enzyme that converts 5-fluorocytosine,an oral anti-fungal agent , into the potent anticancer agent 5-fluorouracil.. The conversion occurs only at the site of gene expression, the company said.
Rockville, Md --GenVec has begun a phase I study of its in vivogene-based product, AdgvCD. 10, in 18 patients with liver metastasesof colectoral cancer . An advenovirus vector modified to carrythe cytosine deaminase gene will be administered directly intothe hepatic tumor. The gene expresses an enzyme that converts5-fluorocytosine,an oral anti-fungal agent , into the potent anticanceragent 5-fluorouracil.. The conversion occurs only at the siteof gene expression, the company said.
![We must work on clinical predictors based on the disease phenotype, we must work on the physician’s attitude, and [we must work to] stimulate the correct and timely usage of ruxolitinib.](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fcancernetwork%2Fd5a069c33bbfe917bc7c0b1bb13d76c0a815cc44-234x234.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 "We must work on clinical predictors based on the disease phenotype, we must work on the physician’s attitude, and [we must work to] stimulate the correct and timely usage of ruxolitinib.")
