Jan A. Burger, MD, PhD, on CLL Research Coming Out of ASH

News
Video

The leukemia expert discussed exciting research being presented at this year’s ASH Annual Meeting.

In an interview with CancerNetwork®, Jan A. Burger, MD, PhD, of the Department of Leukemia in the Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, discussed influential research being presented at the 62nd American Society of Hematology (ASH) Annual Meeting for patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

Transcription:

Well, as I said, the abstract kind of fits together with data which are presented at this ASH conference, but also published earlier this year, to say if we look at these studies with BTK inhibitors with longer follow up, the survival benefit, especially also for the high-risk patients, is ongoing. So that's very exciting.

The other exciting thing at this conference and last year's ASH abstract is how do we best use and take benefit from these new targeted agents. And the other exciting developments that I see are combination approaches, where we combine BTK inhibitors with other agents, especially with venetoclax (Venclexta), or maybe other BCL-2 antagonists, CD-20 antibodies, in order to get patients into deeper remissions, and then maybe transition from very long term use of BTK inhibitors towards maybe shorter treatment regimen where patients can be treated for a limited time and therefore, have maybe a year or 2 years of treatment with these agents, and then can take a break.

So that's something I think that's going to continue to be interesting. We don't have too many data on that yet, but I think that's going to continue to be an interesting and exciting theme – combination treatments based on BTK inhibitors.

Recent Videos
Data from the phase 3 DeLLphi-304 trial at ASCO 2025 revealed a survival advantage with tarlatamab vs chemotherapy in second-line ES-SCLC.
The FDA approval of tarlatamab in SCLC has received much press attention, according to Daniel R. Carrizosa, MD, MS.
The National ICE-T Conference may inspire future collaboration between community and academic oncologists in the management of different cancers.
One of the largest obstacles to tackle in the kidney cancer landscape will be translating the research on rare kidney cancer subtypes into clinical trials.
Long-term toxicities like infections and secondary primary malignancies remain a concern when sequencing novel agents for those with multiple myeloma.
Zanzalitinib exhibited favorable data when evaluated alone or in combination with anti-PD-1 immune checkpoint inhibition in phase 1 RCC trials.
The investigational agent exhibited superior efficacy vs pembrolizumab in patients with lung cancer, suggesting potential efficacy in kidney cancer.
Management of adverse effects and access to cellular therapies among community oncologists represented key points of discussion in multiple myeloma.
“As a community, if we’re looking to help enroll and advocate for patients with rare [kidney cancers], we need to be aware of what is out there,” said A. Ari Hakimi, MD.
Treatment with the dual inhibitor displayed a short half-life and a manageable toxicity profile in patients with clear cell renal cell carcinoma.
Related Content