Cover Story Father of tamoxifen a Brit to the core Oncologists must make time for fertility issues The flap over flat polyps: How common are they and how significant to the patient? DEPARTMENTS Focus on Colon Cancer Chemoprevention of polyps now a reality Zoledronic acid ups PFS in younger early-stage pts News & Analysis Imaging biomarker can predict early treatment response in malignant glioma Focus on Breast Cancer Study of mammography in older women stirs up controversy Breast cancer vaccine shows survival benefit in subset of low HER2 expressors Focus on Hematology Strong nilotinib responses in imatinib-failed CP-CML NCCN greenlights nilotinib for imatinib-resistant CML patients Focus on Lung Cancer No overall survival benefit for dose-intense regimen in SCLC