Paclitaxel-Encequidar Combo Effective Treatment for Patients with Radiation-Associated Breast Angiosarcoma

Article

The combination of oral paclitaxel and encequidar has the potential to be an effective treatment for patients with radiation-associated breast angiosarcoma.

According to data presented at the 2020 San Antonio Breast Cancer Symposium, the combination of oral paclitaxel and encequidar (oPac+E) has the potential to be an effective treatment for patients with radiation-associated breast angiosarcoma.1

The researchers assessed activity, safety and tolerability of oPac 205 mg/m2 plus E 12.9 mg once daily for 3 consecutive days weekly in patients with unresectable cutaneous angiosarcoma. The primary outcome of the study was tumor response to therapy every 6 weeks.

From August 2018 to May 2020, 7 patients (median age, 66 years; range, 49-76) were diagnosed with breast cutaneous angiosarcoma. All patients had previously been diagnosed with breast cancer and received a mastectomy and radiotherapy and/or adjuvant chemotherapy.

Three patients (43%) achieved a complete response on the combination, and also achieved stable disease (43%). One patient achieved a partial response to therapy. Forty-three percent of patients crossed over to receive curative surgical resection.

The combination was generally well tolerated, with grade 3 treatment-related adverse events (TRAEs) occurring in 5 patients. The most common grade 3 TRAEs included fatigue (2 cases), diarrhea, dyspnea, dehydration, pneumonitis and neutropenia (one case each). Three patients needed dose reductions, however there were no treatment discontinuations as a result of AEs. No patient deaths have been reported to date.

The authors concluded that the combination may be an effective oral treatment for patients with radiation-associated breast angiosarcoma, with limited toxicities, which could offer patients the potential to avoid intravenous chemotherapy at a hospital.

Reference:

Ravi V, Wagner M, Chen TWW, et al. A phase 2 study of oral paclitaxel and encequidar (oPac+E) in the treatment of cutaneous angiosarcoma: The breast angiosarcoma subgroup. Presented at: 2020 San Antonio Breast Cancer Symposium; December 8-11; 2020; Virtual. Poster PS13-05.

Recent Videos
Future research will aim to assess the efficacy of PIPAC-MMC plus systemic therapy vs systemic therapy alone in patients with peritoneal tumors.
Although small incision surgery may serve as a conduit to deliver PIPAC-MMC, it may confer benefits in the staging and treatment of peritoneal tumors.
Patients with peritoneal metastases were historically associated with limited survival and low consideration for clinical trials.
Findings from the OVARIO study show that patients with HRR–deficient and BRCA-mutated disease benefitted the most from niraparib/bevacizumab maintenance.
Select comorbidities, ECOG status, and the receipt of radiation were among the differences between a real-world cohort and the RUBY trial population.
Related Content