Phase I Data on SAHA, a Histone Deacetylase Inhibitor

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Oncology NEWS InternationalOncology NEWS International Vol 12 No 1
Volume 12
Issue 1

TARRYTOWN, New York-Aton Pharma, Inc and its collaborators presented phase I data on its oral histone deacetylase inhibitor SAHA (suberoylanilide hydroxamic acid) at the 14th Annual EORTC/NCI/AACR symposium, held in Frankfurt, Germany. The trial of patients with refractory solid tumors, lymphomas, and leukemias, being conducted with researchers at Memorial Sloan-Ket-tering Cancer Center, defined a safe daily oral dosing regimen.

TARRYTOWN, New York—Aton Pharma, Inc and its collaborators presented phase I data on its oral histone deacetylase inhibitor SAHA (suberoylanilide hydroxamic acid) at the 14th Annual EORTC/NCI/AACR symposium, held in Frankfurt, Germany. The trial of patients with refractory solid tumors, lymphomas, and leukemias, being conducted with researchers at Memorial Sloan-Ket-tering Cancer Center, defined a safe daily oral dosing regimen.

Evidence of antitumor activity was also observed. Of the 28 patients with solid tumors, one (larynx cancer) had a partial response, two (renal cell cancer and transitional cell cancer) had reduction in measurable disease, and one (papillary thyroid cancer) had stable disease for more than 2 months.

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Phase II Trial of Phenoxodiol in Recurrent Ovarian Cancer Is launched
FDA Approves New Taxotere Indication as First-Line Therapy for NSCLC
Most Cancer Pain Is Experienced at the Patient’s Home
HHS Unites Its HIV Advisors
First NCI Health Disparity Grants
Pain Therapy Improves Quality of Life for Caregivers
Inex to Seek FDA Approval for Onco TCS (Liposomal Vincristine)
CD40L-Expressing Dendritic Cells Eliminate Breast Tumors in Mice
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Lumpectomy/Mastectomy Equivalent in Early Breast Cancer
New Agent Tested in Refractory and Relapsed Ovarian Cancer
HIV Testing of Pregnant Women Increases: CDC Report
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