Shubham Pant, MD, Highlights the Potential of ELI-002 2P to Treat MRD in KRAS-Mutant Solid Malignancies

News
Video

Shubham Pant, MD, spoke to the potential of ELI-002 2P as a treatment for minimal residual disease positivity in patients with KRAS-mutant solid tumors.

In an interview with CancerNetwork® during the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, Shubham Pant, MD, associate professor in the Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine at the University of Texas MD Anderson Cancer Center, spotlighted the ongoing phase 1 AMPLIFY-201 trial (NCT04853017) assessing ELI-002 2P in patients with KRAS-mutant with solid tumors that were positive for minimal residual disease by circulating tumor DNA (ctDNA).

Transcript:

The abstract I presented this morning was [about a] trial in progress. It’s very important for [oncology professionals] to know about which trials are ongoing that could have a patient care impact. We had a very interesting trial of patients with minimal residual disease in solid tumors. Now that concept has made it in the mainstream more in leukemia and [other] hematologic malignancies, but it’s coming to the forefront in patients with solid tumor malignancies. What we are doing in this trial is [examining] patients with resected colon cancer even with resected liver metastases, pancreatic cancer, ovarian cancer, non–small cell lung cancer, or biliary tract cancers who have no evidence of disease. When we do a scan, there’s no evidence of disease; but when we take their blood sample for ctDNA, they’re positive. Then, they can get an experimental vaccine targeted against a KRAS mutation.

KRAS has long been called undruggable, but there are a lot of different small molecules and vaccine therapies that are trying to change the tide. I’m really excited about this trial [and there is] a lot of enthusiasm from other investigators. [It] is ongoing at our institution and multiple other institutions.

Reference

Pant S, Furqan M, Muhsin R, et al. First-in-human phase 1 trial of ELI-002 immunotherapy as treatment for subjects with Kirsten rat sarcoma (KRAS)-mutated pancreatic ductal adenocarcinoma and other solid tumors. J Clin Oncol. 2022;40(suppl 16):TPS2701. doi:10.1200/JCO.2022.40.16_suppl.TPS2701

Recent Videos
Epistemic closure, broad-scale distribution, and insurance companies are the 3 largest obstacles to implementing new peritoneal surface malignancy care guidelines into practice.
Shebli Atrash, MD, stated that MRD should be considered carefully as an end point, given potential recurrence despite MRD negativity.
“This is something where this is written by the trainees, for the trainees, and, of course, for all the other clinicians who take care of patients,” said Kiran Turaga, MD, MPH.
Data from the phase 3 DeLLphi-304 trial at ASCO 2025 revealed a survival advantage with tarlatamab vs chemotherapy in second-line ES-SCLC.
The FDA approval of tarlatamab in SCLC has received much press attention, according to Daniel R. Carrizosa, MD, MS.
These new guidelines aim to alleviate some of the problems caused by patients with peritoneal metastases being diagnosed with the disease in late stages.
The National ICE-T Conference may inspire future collaboration between community and academic oncologists in the management of different cancers.
One of the largest obstacles to tackle in the kidney cancer landscape will be translating the research on rare kidney cancer subtypes into clinical trials.
Long-term toxicities like infections and secondary primary malignancies remain a concern when sequencing novel agents for those with multiple myeloma.
Zanzalitinib exhibited favorable data when evaluated alone or in combination with anti-PD-1 immune checkpoint inhibition in phase 1 RCC trials.
Related Content