ESMO’s president, Solange Peters, MD, PhD, discussed a handful of key abstracts presented during the 3 Presidential Symposia sessions at the 2021 ESMO Congress.
CancerNetwork spoke with Solange Peters, MD, PhD, head of the medical oncology service and chair of thoracic oncology in the Oncology Department at the Centre Hospitalier Universitaire Vaudois and president of the European Society for Medical Oncology (ESMO), about key abstracts that read out at the 2021 ESMO Congress. Several of the trials, including the phase 3 DESTINY-Breast03 trial (NCT03529110), examining the use of fam-trastuzumab deruxtecan-nxki (Enhertu) vs trastuzumab emtansine (Kadcyla; T-DM1) in patients with HER2-positive metastatic breast cancer, as well as the phase 3 KEYNOTE-826 trial (NCT03635567), which assessed pembrolizumab (Keytruda) plus chemotherapy compared with chemotherapy alone in metastatic cervical cancer.
Transcription:
So, there are 3 Presidential [Symposia], which encompass the definition of practice changing abstracts… We have trastuzumab deruxtecan vs TDM-1 in HER2-positive metastatic breast cancer,1 [which is an] amazing trial. We have pembrolizumab plus chemotherapy vs chemotherapy for metastatic cervical cancer2, which is not-so-often observed in big sessions [and is] an amazing trial, too. Very important is the extension of the pembrolizumab indication in the [adjuvant] melanoma setting3, [which was] also presented today.
Tomorrow, we have also 2 breaking news [presentations] in castration-sensitive prostate cancer—one in early and 1 in late disease [with] these new combinations of drugs.4 We have the KRAS inhibitor adagrasib plus cetuximab (Erbitux), which also [has] amazing data in colorectal cancer.5 We [also] have [nivolumab]/chemotherapy in gastric cancer.6
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