Stereotactic Radiation Offers ‘Another Modality’ for the Management of Metastatic Kidney Cancer, Says Expert

Video

An expert from the University of Texas Southwestern Medical Center in Dallas emphasized that stereotactic radiation provides oncologists with an alternative modality for treating patients with kidney cancer for whom standard ablative surgery is not an option.

Community urologists should consider stereotactic radiation therapy as another clinically useful tool for treating patients with kidney cancer, according to Raquibul Hannan, MD, PhD, a professor in the Department of Radiation Oncology, Urology and Immunology at the University of Texas Southwestern Medical Center in Dallas.

During the 2022 Society for Urologic Oncology (SUO) Annual Meeting, CancerNetwork® spoke with Hannan regarding his presentation on the use of stereotactic radiation for managing metastatic kidney cancer.

Hannan suggests that stereotactic radiation therapy would be beneficial in cases where patients with metastatic kidney cancer are ineligible or unsuitable for receiving treatment with ablation or surgery.

“For all of those patients, [community urologists] should keep in mind that stereotactic radiation is there,” he said.

Transcript:

The community urologists should really take [stereotactic radiation] as another modality, another arsenal at their disposal to help their patients. Some patients are definitely not candidates [for surgery]. Some patients have bigger tumors that are not applicable for treatment with ablation. Some patients are just too frail to go through surgery, or they may have only a single kidney that [for which] nephrectomy is not possible. For all of those patients, they should keep in mind that stereotactic radiation is there. That offers more than 90% local control, and it is something that they can offer to their patients.

Recent Videos
Data from the phase 3 DeLLphi-304 trial at ASCO 2025 revealed a survival advantage with tarlatamab vs chemotherapy in second-line ES-SCLC.
The FDA approval of tarlatamab in SCLC has received much press attention, according to Daniel R. Carrizosa, MD, MS.
The National ICE-T Conference may inspire future collaboration between community and academic oncologists in the management of different cancers.
One of the largest obstacles to tackle in the kidney cancer landscape will be translating the research on rare kidney cancer subtypes into clinical trials.
Long-term toxicities like infections and secondary primary malignancies remain a concern when sequencing novel agents for those with multiple myeloma.
Zanzalitinib exhibited favorable data when evaluated alone or in combination with anti-PD-1 immune checkpoint inhibition in phase 1 RCC trials.
The investigational agent exhibited superior efficacy vs pembrolizumab in patients with lung cancer, suggesting potential efficacy in kidney cancer.
Management of adverse effects and access to cellular therapies among community oncologists represented key points of discussion in multiple myeloma.
“As a community, if we’re looking to help enroll and advocate for patients with rare [kidney cancers], we need to be aware of what is out there,” said A. Ari Hakimi, MD.
Treatment with the dual inhibitor displayed a short half-life and a manageable toxicity profile in patients with clear cell renal cell carcinoma.
Related Content