Ursula A. Matulonis, MD, Discusses Rationale for Assessing Mirvetuximab Soravtansine in FRα-High Ovarian Cancer

Video

Ursula A. Matulonis, MD, highlights the rationale behind studying mirvetuximab soravtansine (IMGN853) as a therapy for patients with folate receptor α (FRα)–high platinum-resistant ovarian cancer.

During The Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer, Ursula A. Matulonis, MD, Brock-Wilson Family Chair and chief of the Division of Gynecologic Oncology at Dana-Farber Cancer Institute as well as professor of medicine at Harvard Medical School, spoke with CancerNetwork® about the rationale for assessing mirvetuximab soravtansine (IMGN853) in patients with folate receptor α (FRα)–high platinum-resistant ovarian cancer.

In particular, she highlights the population of the phase 3 SORAYA trial (NCT04296890), which included patients who had previously received bevacizumab (Avastin). She also stated that those with high-grade serous ovarian cancer are likely to have high levels of FRα, making them a potential good fit for treatment with mirvetuximab soravtansine.

Transcript:

This is a phase 3 study for patients with FRα-high, or FRα-positive, platinum-resistant ovarian cancer. Patients were required to have prior bevacizumab and they could [have received] up to 3 lines of prior treatment, and they could also have received PARP inhibitors. The rationale [behind this trial is rooted in the fact that] high-grade serous ovarian cancer is a cancer that has high levels of FRα. In high-grade serous [disease], high levels are present in about 40% of patients’ cancers. The rationale has been that in pooled trials, we’ve seen response rates that are near 30% in a very similarly designed and selected patient populations as in SORAYA.

Reference

Matulonis UA, Lorusso D, Oaknin A, et al. Efficacy and safety of mirvetuximab soravtansine in patients with platinum-resistant ovarian cancer with high folate receptor alpha expression results from the SORAYA study. Presented at: 2022 SGO Annual Meeting on Womens’ Cancers; March 18-21, 2022; Phoenix, AZ. Abstract 242.

Recent Videos
The National ICE-T Conference may inspire future collaboration between community and academic oncologists in the management of different cancers.
One of the largest obstacles to tackle in the kidney cancer landscape will be translating the research on rare kidney cancer subtypes into clinical trials.
Long-term toxicities like infections and secondary primary malignancies remain a concern when sequencing novel agents for those with multiple myeloma.
Zanzalitinib exhibited favorable data when evaluated alone or in combination with anti-PD-1 immune checkpoint inhibition in phase 1 RCC trials.
The investigational agent exhibited superior efficacy vs pembrolizumab in patients with lung cancer, suggesting potential efficacy in kidney cancer.
Management of adverse effects and access to cellular therapies among community oncologists represented key points of discussion in multiple myeloma.
“As a community, if we’re looking to help enroll and advocate for patients with rare [kidney cancers], we need to be aware of what is out there,” said A. Ari Hakimi, MD.
Treatment with the dual inhibitor displayed a short half-life and a manageable toxicity profile in patients with clear cell renal cell carcinoma.
The annual Kidney Cancer Research Summit was born from congressional funding for kidney cancer research, according to KidneyCAN president Bryan Lewis.
Combining renal vaccines with immune therapy may better target tumor cells while limiting harm to healthy tissue, according to David A. Braun, MD, PhD.
Related Content