Ann F. Chambers, PhD

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Articles

Evaluating the Role of Serine Protease Inhibition in the Management of Tumor Micrometastases

Joe B. Putnam, Jr, MD, FACS;David Royston, MD;Ann F. Chambers, PhD;Scott Dunbar, MD;John H. Lemmer, Jr, MD;Peter Norman, MD;Elizabeth Travis, PhD;Ara A. Vaporciyan, MD;Stephen Yang, MD, FACS;Leo R. Zacharski, MD

October 1st 2003

Conservation of blood is apriority during surgery, owingto shortages of donor bloodand risks associated with transfusionof blood products.[9,10] However,blood transfusions have been linkedto a number of negative postoperativesequelae, including poorer prognosisafter cardiac and cancer surgery.[11-21] In this context, recognition thatallogeneic transfusion-associatedimmunomodulation can increasemorbidity in allogeneically transfusedpatients has become a major concernin transfusion medicine.[9,22,23]