Lymphoma

A study investigates whether R-CHOP is a viable first-line treatment for patients with advanced follicular lymphoma.

A phase III study looks at the efficacy and safety of rituximab biosimilar CT-P10 in patients with follicular lymphoma.

Researchers discovered clinical and experimental evidence that calls into question the widely held notion that LSCs preferentially outlive chemotherapy.

The ground-breaking study, led by the Leukemia & Lymphoma Society, is evaluating several novel targeted therapies for acute myeloid leukemia.

Cancer patients in England will receive a new game-changing therapy treatment under the first negotiated deal of its kind struck in Europe.

An inflammation marker was associated with several unfavorable characteristics in diffuse large B-cell lymphoma.

New research evaluated whether symptomatic indolent follicular lymphoma requires new long-term therapy after first-line rituximab without chemotherapy.

Evaluating the prognostic value of PET-CT responses after first-line immunochemotherapy in follicular lymphoma.

The research, published in JAMA Oncology, evaluates survival outcomes of a second allogeneic hematopoietic cell transplant vs donor lymphocyte infusion.

A study in The Lancet Haematology suggests this combination could become first-line for elderly or unhealthy patients with newly diagnosed AML.

A study shows undergoing treatment for DLBCL at a clinic with more experience was linked with important clinical outcomes.

Plasma fibrinogen tests should be encouraged routinely in clinical practice to clarify its predictive benefit, according to a study.

Dr. Andrew Zelenetz spoke with Cancer Network about the importance of determining the cell of origin in patients with DLBCL.

In this article, we review the methods of determining cell of origin (COO); use of COO in clinical practice; clinical trials in DLBCL according to COO; and future directions of tailoring treatment, including alternate categorization of genetic subtypes or clusters in DLBCL.

A study shows expanding access to care through insurance has the potential to improve outcomes in adults with follicular lymphoma.

A study shows pretreatment ctDNA levels and molecular responses are independently prognostic of outcomes in lymphomas.

How much do you know about the clinical course and genomics of follicular lymphoma? Take our latest quiz to find out.

Antiretroviral therapy and rituximab show promise in aids-related diffuse large B-cell lymphoma patients.

Recent studies on CAR T-cell immunotherapy, and the recent approval of a new agent, add to evidence supporting the efficacy of these therapies.

Balancing the goal of obtaining a durable remission and that of avoiding a negative impact on quality of life argues against the routine use of chemotherapy in follicular lymphoma.

It is clear that chemoimmunotherapy has redefined the history of follicular lymphoma, producing survival rates measured in decades.

DLBCL and FL patients experience considerable economic burden during the first year after diagnosis.

The combination of obinutuzumab and lenalidomide was found to be effective in relapsed or refractory follicular B-cell lymphoma.

New data support PFS as a surrogate endpoint for OS in future trials evaluating chemoimmunotherapy in DLBCL.

In the DBL3001 trial, the combination of ibrutinib and R-CHOP was not superior to treatment with R-CHOP alone.

In addition to significant improvements in 5-year OS and PFS with maintenance rituximab, there was a trend toward an association between maintenance and reduced transformation risk.

TROG 99.03 constitutes “the only high level evidence currently available to guide decision making for this group of patients,” says investigator Michael MacManus.

There may be prophylactic benefit from using lenalidomide, an orally bioavailable CNS-penetrating agent, combined with R-CHOP in the upfront setting.

The OS benefit associated with standard treatment diminished in patients older than 80 with high comorbidity scores, but other age groups fared better.

De-escalated treatment may be possible in patients with advanced HL who reach a metabolic response after only 2 cycles of escalated BEACOPP.