How Will Indolent Lymphoma/B-Cell NHL Care Be Improved in the Future?
There will be an unmet need for therapy in patients with aggressive lymphomas who did not benefit from therapy with bispecifics, CAR-T, chemotherapy, and targeted therapy.
SC Mosunetuzumab Will Be Accessible for MZL Care in Community Settings
The subcutaneous formulation of mosunetuzumab will require 17 cycles of therapy, without any maintenance, and can be done in outpatient settings.
Which Therapy Has the Best Efficacy in Transplant-Ineligible NDMM?
D-VRd had a 72% chance of providing superior PFS outcomes vs isatuximab plus VRd in patients with transplant-ineligible NDMM.
What AEs Should Physicians Be Aware of With Bispecifics in Indolent Lymphoma?
Respiratory, viral, and bacterial infections have emerged as a toxicity of note during bispecific antibody treatment for indolent lymphoma.
What Chemo-Free Immunotherapy Combos Have Potential in Indolent Lymphomas?
Lorenzo Falchi, MD, highlighted the phase 1b/2 EPCORE NHL-2 and phase 1 BP41072 trials as prominent trials evaluating novel immunotherapy combinations in indolent lymphoma.
Are Novel Immunotherapy Combos Effective for Indolent Lymphoma Care?
Bispecific antibodies have demonstrated adaptability and versatility when combined with immunotherapy and chemotherapy agents.
How Effective, Safe is Mosunetuzumab/Polatuzumab Vedotin in Pretreated MCL?
Treatment with mosunetuzumab and polatuzumab vedotin led to a complete response rate of 79% in patients with mantle cell lymphoma.
Who Should Receive Mosunetuzumab/Polatuzumab Vedotin as MCL Treatment?
Mosunetuzumab plus polatuzumab vedotin demonstrated efficacy in subgroups of patients with mantle cell lymphoma with poor risk factors.
Mosunetuzumab Combo Yields Differentiated Safety Profile Vs SOC in LBCL
According to Adam J. Olszewski, MD, M-Pola’s safety profile makes it administrable in community settings to those with transplant-ineligible RLBCL.
Mosunetuzumab Combo May Save Lives in Mantle Cell Lymphoma
The mosunetuzumab and polatuzumab vedotin combination was evaluated in a high-risk factor subgroup of patients with mantle cell lymphoma.
Was Mosunetuzumab/Polatuzumab Vedotin Efficacious in LBCL Subtype?
Although OS data are still immature, they have shown favorable trends for mosunetuzumab and polatuzumab vedotin in transplant-ineligible LBCL.
Breaking Down The SUNMO Trial on M-Pola in ASCT-Ineligible R/R LBCL
Results from the SUNMO trial may show that M-Pola is a viable treatment option for those with transplant-ineligible relapsed/refractory LBCL.
Is There Space for Single-Agent Mosunetuzumab in Frontline MZL Care?
Results from the phase 2 MorningSun trial demonstrated that outpatient, subcutaneous single-agent mosunetuzumab was efficacious in patients with marginal zone lymphoma.
Mosunetuzumab Treatment Combo Yields Responses in High-Risk MCL
Michael Wang, MD, stated that results from this phase 2 trial were tremendous and showed that mosunetuzumab plus polatuzumab vedotin is viable in MCL.
Will Ziftomenib Be Approved in NPM1-Mutated R/R Acute Myeloid Leukemia?
Several ongoing trials are evaluating the efficacy of ziftomenib treatment combinations in this acute myeloid leukemia population.
Unraveling Key Blood Cancer Takeaways From the 2025 SOHO Meeting
Experts detailed key advances in myelofibrosis, multiple myeloma, and lymphoma at the Society of Hematologic Oncology 2025 Annual Meeting.
Ziftomenib Achieves Responses and is Safe in NPM1+ R/R AML
Single-agent ziftomenib achieved an ORR of 35% in patients with relapsed/refractory acute myeloid leukemia harboring an NPM1 mutation.
Why Evaluate Single-Agent Ziftomenib in NPM1+ R/R Acute Myeloid Leukemia?
New targeted therapies are needed to improve outcomes for patients with NPM1-mutant relapsed/refractory acute myeloid leukemia.
Managing and Understanding Toxicities Associated With Myelofibrosis Therapy
All 4 FDA-approved JAK inhibitors for myelofibrosis have unique toxicity profiles that all patients and physicians should know, said Prithviraj Bose, MD.
How Promising Are Immunotherapy Combos in Indolent Lymphoma?
Lorenzo Falchi, MD, highlighted the most important considerations when using novel immunotherapy combination therapies for patients with indolent lymphoma.
Understanding Predictive Markers Drives Ruxolitinib Usage in Myelofibrosis
According to Francesca Palandri, MD, PhD, ruxolitinib will have a less significant effect in patients with myelofibrosis who have a cytopenic phenotype.
Determining Molecular Mutations Driving Decisions in Myelofibrosis Therapy
Non-driver mutations can be informative for clinicians in the treatment of patients with myelofibrosis, as they may help guide transplantation decisions.
Understanding The Nuance and Individualization of Myelofibrosis Treatment
There are 4 JAK inhibitors approved for myelofibrosis, all of which are usable in certain situations depending on a patient’s clinical factors.
Evaluating Single-Agent Ziftomenib’s Performance in NPM1+ R/R AML
Ziftomenib yielded a median overall survival of 16.4 months in responders with NPM1-mutant AML who received ziftomenib in the phase 1b/2 KOMET-001 trial.
What Makes M-Pola Superior to R-GemOx in Transplant-Ineligible LBCL?
Results from the SUNMO trial showed that mosunetuzumab plus polatuzumab vedotin achieved a complete response rate of 51.4% in this LBCL population.
Evaluating the Current Myelofibrosis Treatment Paradigm
Interferons and other anemia-driven therapies for myelofibrosis are exciting for the future, according to Prithviraj Bose, MD.
Evaluating the Proximity and Impact of a Cure in Multiple Myeloma
According to Sundar Jagannath, MBBS, the cure for multiple myeloma was observed in patients who were cancer free for 5 years without maintenance therapy.
Effective Communication is Necessary for Pathologists to Make Accurate Diagnoses
In community settings, offices may have to send pathology specimens to reference labs, and it may be difficult to maintain effective communication.
Evaluating the Evolution of Myelodysplastic Syndrome Diagnostic Criteria
Morphological dysplasia is the cornerstone of making a myelodysplastic syndrome diagnosis, except for a few myelodysplastic syndrome–defining genetic alterations.
The Clinical Implications of Having a “Cure” in Multiple Myeloma
Sundar Jagannath, MBBS, said that when a cure is defined for patients with multiple myeloma, specific patients may be able to stop therapy without a risk of relapsing.