Armin Ghobadi, MD, on Recent Advancements in the Treatment of Patients with DLBCL

News
Video

An expert in the treatment of diffuse large B-cell lymphoma explained some of the exciting advances in treatment and hypothesized what comes next after the 2020 ASH Annual Meeting & Exposition.

In an interview with CancerNetwork®, Armin Ghobadi, MD, of the Washington University School of Medicine in St. Louis, explained some of the exciting advances in the treatment of diffuse large B-cell lymphoma (DLBCL) and hypothesized what’s to come following the 2020 American Society of Hematology (ASH) Annual Meeting & Exposition.

Transcription:

There have been a lot of advances in treatment of DLBCL, including multiple T-cell engagers and CAR [chimeric antigen receptor] T-cell [therapies] going after CD19, [CD]20, or other targets. The research in this field is expanding rapidly and dramatically.

Even when you use CAR T-cell therapy—that’s the most effective treatment for relapsed/refractory DLBCL—long-term survival, at least 2 to 3 years disease-free survival [rates are] 35% to 40%. And those patients that relapse don’t have good options. There is still a need for improvement there, especially combining these interesting modalities the same way that we combined CHOP [cyclophosphamide, doxorubicin, vincristine, and prednisone], to come up with a good strategy to cure patients with DLBCL. Combining these newer modalities of T-cell engagers, CAR T-cell [therapies], antibodies drug conjugates, and those kinds of things all together early on for patients that did relapse early [may be necessary] to cure more patients.

Recent Videos
Future findings from a translational analysis of the OVATION-2 trial may corroborate prior clinical data with IMNN-001 in advanced ovarian cancer.
The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
The use of chemotherapy trended towards improved recurrence-free intervals in older patients with high-risk tumors as determined via the MammaPrint assay.
Use of a pharmacist-directed resource appears to improve provider confidence and adverse effect monitoring for patients undergoing infusion therapy.
Reshma L. Mahtani, DO, describes how updates from the DESTINY-Breast09, ASCENT-04, and VERITAC-2 trials may shift practices in the breast cancer field.
Co-hosts Kristie L. Kahl and Andrew Svonavec highlight what to look forward to at the 2025 ASCO Annual Meeting, from hot topics and emerging trends to travel recommendations.
Prior studies, like the phase 3 VISION trial, may support the notion of combining radiopharmaceuticals with best supportive care.
CAR T-cell therapy initially developed for mantle cell lymphoma was subsequently assessed in marginal zone lymphoma.
The efficacy of the BOVen regimen in chronic lymphocytic leukemia facilitated its evaluation in patients with mantle cell lymphoma.
Beta emitters like 177Lu-rosopatamab may offer built-in PSMA imaging during the treatment of patients with metastatic castration-resistant prostate cancer.
Related Content