ASTRO 2017: Highlights in Advanced Lung Cancer

Video

This video highlights studies on advanced lung cancer with practice-changing potential presented at the 2017 ASTRO Annual Meeting.

In this video, Maria Werner-Wasik, MD, of Thomas Jefferson University Hospital in Philadelphia, discusses selected studies on the treatment of lung cancer presented at the 2017 American Society for Radiation Oncology (ASTRO) Annual Meeting, held September 24–27 in San Diego.

Werner-Wasik was the discussant for a session on lung cancer that featured the following abstracts, which were selected for their importance and practice-changing potential:

Abstract 223: Quality of life (QOL) outcomes in a phase III randomized trial of optimization of treatment of advanced non–small-cell lung cancer using radiotherapy and chemotherapy: IAEA multicentric randomized phase III study (NCT00864331)

Abstract LBA-3: Consolidative radiotherapy for limited metastatic non–small-cell lung cancer (NSCLC): a randomized phase II trial

Abstract LBA-4: PACIFIC: A double-blind, placebo-controlled phase III study of durvalumab as consolidation therapy after chemoradiation in patients with locally advanced, unresectable NSCLC

Abstract 227: Long-term results of RTOG 0617; a randomized phase III comparison of standard dose vs high-dose conformal chemoradiotherapy +/- cetuximab for stage III non–small-cell lung cancer

Abstract 33: Long-term follow-up on NRG Oncology RTOG 0915 (NCCTG N0927): A randomized phase II study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage I peripheral non–small-cell lung cancer

Recent Videos
The FirstLook liquid biopsy, when used as an adjunct to low-dose CT, may help to address the unmet need of low lung cancer screening utilization.
An 80% sensitivity for lung cancer was observed with the liquid biopsy, with high sensitivity observed for early-stage disease, as well.
Patients who face smoking stigma, perceive a lack of insurance, or have other low-dose CT related concerns may benefit from blood testing for lung cancer.
Patrick Oh, MD, highlights next steps for further research in treating patients with systemic therapy in addition to radiotherapy for early-stage NSCLC.
Increased use of systemic therapies, particularly among patients with high-risk node-negative NSCLC, were observed following radiotherapy.
Heather Zinkin, MD, states that reflexology improved pain from chemotherapy-induced neuropathy in patients undergoing radiotherapy for breast cancer.
A prospective trial may help affirm ctDNA as a non-invasive option of predicting responses to radiotherapy among those with gynecologic cancers.
Interest in novel therapies to improve outcomes initiated an investigation of the use of immunotherapy in early-stage non-small cell lung cancer.
ctDNA reductions or clearance also appeared to correlate with a decrease in disease burden during the pre-boost phase of radiotherapy.
Investigators evaluated ctDNA as a potentially noninvasive method to predict response to radiotherapy among those with gynecologic malignancies.