Declan Murphy on Theranostics and Future of PSMA PET/CT for Prostate Cancer

Video

Declan Murphy talked about the future of PSMA theranostics to target metastatic castration-resistant prostate cancer.

From the 2020 SUO Meeting, Professor Declan Murphy, of the Peter MacCallum Cancer Centre, spoke with CancerNetwork about the future of PSMA PET/CT imaging and the looming advancements with PSMA theranostics.

Transcription:

But finally, the really, really big area looming on the horizon is PSMA theranostics. So, because we know the PSMA molecule is overexpressed on aggressive prostate cancer, especially for example metastatic castration-resistant prostate cancer, we can actually target that using theranostic agents. So, when the PET scan shows lots of this avidity and so on, we can then label a PSMA molecule with a therapy molecule like for example lutetium-177, a beta-emitter. Effectively you can inject this combined ligand with the PSMA ligand and the lutetium, and the lutetium will be brought to the sites of disease.

So, I think this area will be one in which we will have many, many opportunities to see how we can improve outcomes for patients because these therapy projects will be easier to measure in terms of oncologic outcomes compared to the diagnostic opportunities we already have with PSMA PET/CT. So, I think it’s a very exciting decade or more ahead for those interested in PSMA and prostate cancer.

Recent Videos
Future findings from a translational analysis of the OVATION-2 trial may corroborate prior clinical data with IMNN-001 in advanced ovarian cancer.
The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
The use of chemotherapy trended towards improved recurrence-free intervals in older patients with high-risk tumors as determined via the MammaPrint assay.
Use of a pharmacist-directed resource appears to improve provider confidence and adverse effect monitoring for patients undergoing infusion therapy.
Reshma L. Mahtani, DO, describes how updates from the DESTINY-Breast09, ASCENT-04, and VERITAC-2 trials may shift practices in the breast cancer field.
Co-hosts Kristie L. Kahl and Andrew Svonavec highlight what to look forward to at the 2025 ASCO Annual Meeting, from hot topics and emerging trends to travel recommendations.
Prior studies, like the phase 3 VISION trial, may support the notion of combining radiopharmaceuticals with best supportive care.
Beta emitters like 177Lu-rosopatamab may offer built-in PSMA imaging during the treatment of patients with metastatic castration-resistant prostate cancer.
Ongoing ctDNA analysis may elucidate outcomes associated with divarasib plus migoprotafib for those with KRAS G12C–positive NSCLC.
Related Content