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Environmental Links to Breast Cancer

July 1, 2001
Publication
Article
OncologyONCOLOGY Vol 15 No 7
Volume 15
Issue 7

Two senators have introduced legislationaimed at exploring potential links between environmental exposure and breast

Two senators have introduced legislationaimed at exploring potential links between environmental exposure and breastcancer.

Sens. Harry Reid (D-Nev) and Lincoln Chafee (R-RI) want to give theNational Institute of Environmental Health Sciences (NIEHS) $30 million for thatpurpose. The Institute would use the money to fund eight research centers aroundthe country. 

The Breast Cancer and Environmental Research Act has beenintroduced into the House by Reps. Nita Lowey (D-NY) and Sue Myrick (R-NC). Inan appearance before a Senate appropriations subcommittee in May, NationalCancer Institute Director Richard Klausner said breast cancer deaths per 100,000women have increased from 83 in 1973 to 118 in 1998. Incidence rates areincreasing by about 1% a year for white women and remain unchanged forAfrican-American women. 

Women have a 1-in-8 lifetime risk of contracting breastcancer, and half of the incidence can be explained by currently known riskfactors, such as gene mutations. 

Dr. Klausner did not mention environmentalcauses as potentially contributing to the other half of incidence. Sen. Reid hasexpressed concern about the development of cancer in former nuclear weaponsworkers in Nevada. The NIEHS has considerable experience looking for linksbetween cancer and industrial environments and processes. 

At about the time Sen.Reid was introducing his bill, the NIEHS was releasing a report on a study in1,400 women in the northeast that showed no link between breast cancer and theindustrial chemicals DDT and PCB.

Articles in this issue

Clinical Radiation Oncology
Gemcitabine Active in Patients With Metastatic Breast Cancer
Docetaxel/Carboplatin Combination Produces Impressive Response in Ovarian Cancer Patients
Irinotecan in Lung and Other Malignancies
Excessive Paperwork Detracts From Patient Care, Professional Mentoring, and Research
Once-Yearly Leuprolide for Advanced Prostate Cancer Available
Older Breast Cancer Patients Benefit From Weekly Administration of Paclitaxel
Environmental Links to Breast Cancer
Bush Administration Considering Physician Ratings
Doxorubicin/Paclitaxel Combination Does Not Expose Breast Cancer Patients to Excessive Cardiac Risk
Atrasentan Prolongs Time to Progression in Prostate Cancer Patients
New Clinical Trial to Investigate Treatment Options After Tamoxifen
Prostate Cancer and Spinal Cord Compression
FDA Grants Priority Review to Capecitabine Plus Docetaxel for Breast Cancer
Current Status of Thalidomide in the Treatment of Cancer
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Findings from David Rimm, MD, PhD, suggest that there may be an inverse relationship between HER2 and TROP2 expression among patients with breast cancer.
Tissue samples collected from patients with breast cancer during treatment may help explore therapy selection and predict toxicities.
Breast cancer care providers make it a goal to manage the adverse effects that patients with breast cancer experience to minimize the burden of treatment.
Social workers and case managers may have access to institutional- or hospital-level grants that can reduce financial toxicity for patients undergoing cancer therapy.
Insurance and distance to a tertiary cancer center were 2 barriers to receiving high-quality breast cancer care, according to Rachel Greenup, MD, MPH.
Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer. Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer.
ADCs demonstrate superior efficacy vs chemotherapy but maintain a similar efficacy profile that requires multidisciplinary collaboration to optimally treat.
According to Aditya Bardia, MD, MPH, FASCO, antibody-drug conjugates are slowly replacing chemotherapy as a standard treatment for breast cancer.
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