First-Line Treatment Options for Metastatic Pancreatic Adenocarcinoma
Panelists discuss how the current first-line treatment landscape for metastatic pancreatic adenocarcinoma includes NCCN-recommended regimens like FOLFIRINOX, gemcitabine plus nab-paclitaxel, and the newest addition NALIRIFOX, with treatment selection guided by toxicity profiles, patient-specific factors, and the importance of germline testing.
EP: 1.First-Line Treatment Options for Metastatic Pancreatic Adenocarcinoma
EP: 2.Insights From The NAPOLI-3 and PRODIGE4 Trials In Metastatic Pancreatic Adenocarcinoma
EP: 3.Managing AEs Associated With the FOLFIRINOX and NALIRIFOX Regimens in Pancreatic Cancer
EP: 4.NAPOLI-3 in Real World Practice: Expert Insights on Data From ASCO GI 2025
EP: 5.Evaluating the Impact Of UGT1A1*28 Status On Tolerability Of NALIRIFOX In mPDAC
EP: 6.NALIRIFOX In Practice: Treatment Strategies for Patients With mPDAC
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In this Cancer Network Frontline Forum program, Dr. Chandana and Dr. Darshil Shah discuss navigating first-line therapy options for metastatic pancreatic adenocarcinoma. Dr. Chandana, a GI medical oncologist from the Cancer and Hematology Centers in Grand Rapids, Michigan, specializes in pancreatic cancer research and drug development. Dr. Shah is a GI medical oncologist and director of the gastrointestinal oncology division at Ironwood Cancer and Research Centers in Phoenix, Arizona.
The program serves as an extension of a previous meeting where expert faculty discussed key clinical data updates for frontline therapy in metastatic pancreatic adenocarcinoma. The two physicians plan to review the latest data and share insights on applying this information to clinical practice. They begin by discussing the current treatment landscape for first-line metastatic pancreatic adenocarcinoma therapy.
Dr. Shah explains that the first-line treatment landscape includes multiple NCCN-recommended regimens for patients with ECOG performance status of 0-1, including FOLFIRINOX, gemcitabine plus nab-paclitaxel, and the newest addition, NALIRIFOX (based on the NAPOLI-3 study). While each regimen demonstrates efficacy, toxicity profiles and patient-specific factors guide treatment selection. Dr. Shah also emphasizes the importance of germline testing, as approximately 10% of pancreatic ductal adenocarcinomas are driven by germline mutations that benefit from platinum-based regimens.
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