INAVO120 Trial Insights and Inavolisib's Emerging Role in the Treatment Armamentarium

Opinion
Video

Panelists discuss how the October 2024 FDA approval of inavolisib in combination with palbociclib and fulvestrant for HR positive (HR+)/ HER2 negative  (HER2-) metastatic breast cancer with a PIK3CA mutation marks a pivotal advancement in precision medicine, highlighting how agents like such as inavolisib, capivasertib, elacestrant, and alpelisib have transformed treatment approaches and expanded therapeutic options for patients.

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The treatment landscape for HR+/HER2- metastatic breast cancer continues to evolve and in October 2024, we saw the FDA approval of inavolisib in combination with palbociclib and fulvestrant for HR+ /HER2- advanced or metastatic BC breast cancer with a PIK3CA mutation. This approval marks another important advancement in precision medicine for our patients.

Can you walk us through the evolution of targeted therapies in HR+/HER2- metastatic breast cancer? How have agents like such as inavolisib, capivasertib, elacestrant, and alpelisib changed our approach to treatment?

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Vinay K. Puduvalli, MD, is featured in this series.
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