Kytril Indicated to Prevent RT-Induced Nausea and Vomiting

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Oncology NEWS InternationalOncology NEWS International Vol 8 No 9
Volume 8
Issue 9

PHILADELPHIA-SmithKline Beecham announced in a press release that the FDA has approved Kytril (granisetron HCl) Tablets, its 5-HT3 receptor antagonist, for the prevention of nausea and vomiting associated with radiation, including total body irradiation (TBI) and fractionated abdominal radiation. Kytril Tablets (2 mg, once daily) are currently indicated for the prevention of nausea and vomiting associated with emetogenic cancer therapies.

PHILADELPHIA—SmithKline Beecham announced in a press release that the FDA has approved Kytril (granisetron HCl) Tablets, its 5-HT3 receptor antagonist, for the prevention of nausea and vomiting associated with radiation, including total body irradiation (TBI) and fractionated abdominal radiation. Kytril Tablets (2 mg, once daily) are currently indicated for the prevention of nausea and vomiting associated with emetogenic cancer therapies.

The approval was based on the review of data from two US trials. In the first trial, 18 patients undergoing TBI for bone marrow transplant received Kytril 1 hour before the first daily radiation fraction. Over the entire 4-day dosing period, 22% of Kytril patients had no vomiting vs 0% of historical controls.

In the second trial, involving 260 patients receiving fractionated upper abdominal radiation, patients given Kytril had a significantly longer time to the first episode of vomiting (35 days vs 9 days for placebo, P < .001) and a significantly longer time to first episode of nausea (11 days vs 1 day, P < .001).

Articles in this issue
‘Gonzalez Diet’ to Be Tested in Pancreatic Cancer
Talking to Members of Congress About Cancer Issues
Modified SPECT Scintimammography Proves More Accurate
Lilly Enjoined From Promoting Evista for Breast Cancer Prevention
Experts Brief Capitol Hill on Trial Costs Survey
NIH Plan Quadruples Prostate Cancer Research Funds
Gabapentin as Adjuvant to Opioids in Neuropathic Pain
Biochemotherapy May Be an Option in Metastatic Melanoma
PET Scans Spare Some NSCLC Patients From Mediastinoscopy
Computer Technique Gives New Life to Thermal Breast Imaging
Kytril Indicated to Prevent RT-Induced Nausea and Vomiting
Human Trials to Begin for Genetically Engineered Salmonella
NCI Awards HMO Group $16 Million for Cancer Studies
Routine Endometrial Biopsy ‘of Limited Value’ in Tamoxifen Users
Sponsors Optimistic Medicare Cancer Clinical Trials Coverage Act Will Pass
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