Many Great Treatments Available for MCL But Questions About Sequencing Remain, Expert Says

News
Video

In a conversation during the 2022 American Society of Hematology Annual Meeting, an expert from the University of Texas MD Anderson Cancer Center, spoke to how treatments have improved for patients with mantle cell lymphoma.

Survival has extended significantly over the years for patients with mantle cell lymphoma as treatments have evolved, but questions around sequencing still remain, according to Hun Ju Lee, MD.

In a conversation with CancerNetwork® during the 2022 American Society of Hematology (ASH) Annual Meeting, Lee, an assistant professor of medicine in the Department of Lymphoma and Myeloma at the University of Texas MD Anderson Cancer Center, also highlighted the importance of shared decision making when treating this patient population.

Transcript:

Historically, when I was starting off, median overall survival for mantle cell lymphoma was three years. Now, it's [somewhere between] 25 to 30 years given the treatment options. There are so many great treatment options. [As to] how we sequence them is still a key question. Which should come first, and which should come after that?

That is really going to incorporate not just the physicians and the oncologist, but you'll need the patient’s input as to what [adverse] effects they are willing to accept. I recognize the risk is taken by the patient, so they really need to be informed of the of the subtleties of the risk that is involved in selecting treatment options.

Recent Videos
Patients with mediastinal lymph node involved-lung cancer may benefit from chemoimmunotherapy in the neoadjuvant setting.
Stressing the importance of prompt AE disclosure before they become severe can ensure that a patient can still undergo resection with curative intent.
Thomas Marron, MD, PhD, presented a session on clinical data that established standards of care for stage II and III lung cancer treatment at CFS 2025.
Sonia Jain, PhD, stated that depatuxizumab mafodotin, ABBV-221, and ABBV-321 were 3 of the most prominent ADCs in EGFR-amplified glioblastoma.
Skin toxicities are common with targeted therapies for GI malignancies but can be remedied by preventative measures and a collaboration with dermatology.
Computational models help researchers anticipate how ADCs may behave in later lines of development, while they are still in the early stages.
ADC payloads with high levels of potency can sometimes lead to higher levels of toxicity, which can eliminate the therapeutic window for patients with cancer.
According to Greg Thurber, PhD, target-mediated uptake is the biggest driver of efficacy for antibody-drug conjugates as a cancer treatment.
Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer. Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer.
Related Content