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Optimal Strategies for Managing Adverse Events with CAR-T Therapy in Multiple Myeloma : Episode 2

Navigating CAR T-Cell Therapy in Multiple Myeloma: A Collaborative, Patient-Centered Approach

June 5, 2024
By Beth Faiman, PhD, CNP
Louis Williams, MD
  • Donna Catamero, ANP-BC, OCN, CCRC
  • Tiffany Richards, PhD, ANP-BC

Opinion
Video

Experts on multiple myeloma discuss how they educate and prepare patients who are going to receive CAR T-cell therapy and provide clinical insights on transitioning patients to community practices following treatment.

EP: 1.Unique Challenges in Managing Adverse Events Associated with CAR T-Cell Therapy

Now Viewing

EP: 2.Navigating CAR T-Cell Therapy in Multiple Myeloma: A Collaborative, Patient-Centered Approach

EP: 3.Patient Profile 1: Managing CRS Following CAR T-Cell Therapy

EP: 4.Underlying Mechanisms and Signs of CRS

EP: 5.Strategies to Manage or Mitigate CRS

EP: 6.Patient Profile 2: Managing ICANS Following CAR T-Cell Therapy

EP: 7.Clinical Practices for Treating ICANS Following CAR T-Cell Therapy

EP: 8.The Importance of Multidisciplinary Collaboration in CRS Management

EP: 9.Supportive Care Strategies for CAR T-Cell Therapy Recipients

EP: 10.Managing Cytopenias and HLH/MAS Following CAR T-Cell Therapy

EP: 11.Unmet Needs and Future Perspectives for CAR T-Cell Therapy in R/R MM

Video content above is prompted by the following questions:

  • How do you prepare patients who are going to receive CAR T-cell therapy? What are you telling them?
Recent Videos
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
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Developers designed cemsidomide as an orally bioavailable small molecule degrader that targets IKZF1/3, which drive multiple myeloma and non-Hodgkin lymphoma.

Cemsidomide Combo May Produce Responses in Multiple Myeloma

Russ Conroy
May 8th 2025
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Investigators of the phase 1/2 CFT7455-1101 study have determined cemsidomide at a dose of 100 µg safe for expansion.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma

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October 14th 2024
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Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.


"[O]ur analysis supports the clinical efficacy and safety of IsaKd as a first-salvage therapy in a specific, and still existing, subset of [patients with multiple myeloma] who relapse during lenalidomide maintenance following autologous stem cell transplantation," according to the study authors.

Salvage Isatuximab Combo Elicits Efficacy in Lenalidomide-Relapsed Myeloma

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Extramedullary disease was the only factor that correlated with worse progression-free survival per multivariate analysis.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

Exploring the Potential Role of JAK Inhibitors in Multiple Myeloma

James R. Berenson, MD, FACP
September 30th 2024
Podcast

James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


“These findings highlight the critical need to address PEM in the management of [patients with multiple myeloma] with ACHF to mitigate the associated poor clinical outcomes,” according to the study authors.

Mortality, Adverse Outcome Odds Higher in Multiple Myeloma PEM Population

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April 28th 2025
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Findings indicate a need to address protein-energy malnutrition in the treatment of those who have multiple myeloma with acute congestive heart failure.


Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

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Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

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Developers designed cemsidomide as an orally bioavailable small molecule degrader that targets IKZF1/3, which drive multiple myeloma and non-Hodgkin lymphoma.

Cemsidomide Combo May Produce Responses in Multiple Myeloma

Russ Conroy
May 8th 2025
Article

Investigators of the phase 1/2 CFT7455-1101 study have determined cemsidomide at a dose of 100 µg safe for expansion.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma

Samantha Shenoy, NP, MSN
October 14th 2024
Podcast

Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.


"[O]ur analysis supports the clinical efficacy and safety of IsaKd as a first-salvage therapy in a specific, and still existing, subset of [patients with multiple myeloma] who relapse during lenalidomide maintenance following autologous stem cell transplantation," according to the study authors.

Salvage Isatuximab Combo Elicits Efficacy in Lenalidomide-Relapsed Myeloma

Russ Conroy
May 3rd 2025
Article

Extramedullary disease was the only factor that correlated with worse progression-free survival per multivariate analysis.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

Exploring the Potential Role of JAK Inhibitors in Multiple Myeloma

James R. Berenson, MD, FACP
September 30th 2024
Podcast

James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


“These findings highlight the critical need to address PEM in the management of [patients with multiple myeloma] with ACHF to mitigate the associated poor clinical outcomes,” according to the study authors.

Mortality, Adverse Outcome Odds Higher in Multiple Myeloma PEM Population

Russ Conroy
April 28th 2025
Article

Findings indicate a need to address protein-energy malnutrition in the treatment of those who have multiple myeloma with acute congestive heart failure.


Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

Roman Fabbricatore
April 27th 2025
Article

Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

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