New Probe Detects Fusion of bcr/abl

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Oncology NEWS InternationalOncology NEWS International Vol 4 No 9
Volume 4
Issue 9

DOWNERS GROVE, Ill--Vysis Inc. has announced the availability of the Locus Specific Identifier (LSITM) bcr/abl translocation probe, a dual-color probe mixture that detects gene fusion of the bcr and abl genes.

DOWNERS GROVE, Ill--Vysis Inc. has announced the availabilityof the Locus Specific Identifier (LSITM) bcr/abl translocationprobe, a dual-color probe mixture that detects gene fusion ofthe bcr and abl genes.

This translocation has been associated with chronic myelogenousleukemia (CML) and acute lymphocytic leukemia (ALL).

The new probe, which is for research use only, is based on proprietaryapplications of FISH (fluorescence in situ hybridization) technology.The probe directly detects target DNA by hybridizing to specificlocations on individual chromosomes, the company said.

Bright Fluorescent Signal

Following hybridization, a bright fluorescent signal is emittedthat can be observed with use of a fluorescence microscope andimaging systems (see figure).

The LSI bcr/abl probe consists of a single probe for bcr (breakpointcluster region), directly labeled with the SpectrumGreenTM fluorochrome,and another probe for the Abelson oncogene (c-abl), directly labeledwith the Spec- trumOrangeTM fluorochrome.

The assay allows the user to quantitatively evaluate both probessimultaneously, either in interphase nuclei or metaphase cells.

Articles in this issue
New Probe Detects Fusion of bcr/abl
Avon's Breast Cancer Crusade to Offer 'Pink Ribbon' Pens
Take a Behind the Scenes Look at ODAC
Michigan Cancer System Named for Woman
Panel Favors Approval of Gemzar for Use In Patients With Late Stage Pancreatic Cancer
High-Dose Chemo Patients to Get Stem Cells With the MDR-1 Gene
Report on Minority Health Finds Few Black Oncologists
Where Are We Going and What Questions Do We Need to Ask?
Phase I Trial of Circadian Patterned Infusion of Continuous IL-2 Opens
Hodgkin's Disease Patients Sought for Trial of MoAb
New Health Care Insurance Reform Legislation Introduced in the Senate
FDA Approves Phase II Trials of Agouron's HIV Protease Inhibitor
House committee Recommends Budget Increases for NIH, NCI
Two New Appointees at the NCI
Chemo Plus Transplant Promising For Advanced Hepatocellular Cancer
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