Ola Landgren, MD, PhD, on Data From CARTITUDE-2 at 2021 ASCO

Video

Ola Landgren, MD, PhD, looks at results from the phase 2 CARTITUDE-2 trial of ciltacabtagene autoleucel for patients with multiple myeloma and 1 to 3 prior lines of therapy presented at the 2021 ASCO Annual Meeting.

At the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, CancerNetwork® spoke with Ola Landgren, MD, PhD, about data from the meeting that he thought was most likely to impact standard of care for patients with multiple myeloma. He cited data regarding the B-cell maturation antigen (BMCA)–targeting chimeric antigen receptor (CAR) T-cell therapy ciltacabtagene autoleucel (cilta-cel) in patients with previously treated disease, which recently received FDA priority review for treatment of the indicated population.

Transcript:

There is so much going on in the myeloma field in 2021, so it’s hard to say which [research] has the strongest or highest clinical impact. I think there is impact every day and it’s changing constantly. Personally, I do think that the new updates for JNJ-4528 [cilta-cel] according to the CARTITUDE-2 trial [NCT04133636] are very exciting to see, [such] that a BCMA-targeted CAR T-cell [therapy] in patients with multiple myeloma who are heavily pretreated has a median duration close to 2 years. I think that’s very, very strong. I think that sends a message that cell therapy could have an important role for many patients.

But also, there was a lot of other activity. All the bispecific antibodies, there are presentations about that too. I’m sure we’ll hear even more details at the [American Society of Hematology Annual Meeting] in December 2021. They are coming with full speed. So how will the future look? We don’t know, but it’s going to look better and better, that’s for sure.

References

Agha ME, Cohen AD, Madduri D, et al. CARTITUDE-2: Efficacy and safety of ciltacabtagene autoleucel (cilta-cel), a BCMA-directed CAR T-cell therapy, in patients with progressive multiple myeloma (MM) after one to three prior lines of therapy. J Clin Oncol. 2021;39(suppl 15):8013. doi:10.1200/JCO.2021.39.15_suppl.8013

Recent Videos
Future findings from a translational analysis of the OVATION-2 trial may corroborate prior clinical data with IMNN-001 in advanced ovarian cancer.
The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
The use of chemotherapy trended towards improved recurrence-free intervals in older patients with high-risk tumors as determined via the MammaPrint assay.
Use of a pharmacist-directed resource appears to improve provider confidence and adverse effect monitoring for patients undergoing infusion therapy.
Reshma L. Mahtani, DO, describes how updates from the DESTINY-Breast09, ASCENT-04, and VERITAC-2 trials may shift practices in the breast cancer field.
Co-hosts Kristie L. Kahl and Andrew Svonavec highlight what to look forward to at the 2025 ASCO Annual Meeting, from hot topics and emerging trends to travel recommendations.
Prior studies, like the phase 3 VISION trial, may support the notion of combining radiopharmaceuticals with best supportive care.
Beta emitters like 177Lu-rosopatamab may offer built-in PSMA imaging during the treatment of patients with metastatic castration-resistant prostate cancer.
Ongoing ctDNA analysis may elucidate outcomes associated with divarasib plus migoprotafib for those with KRAS G12C–positive NSCLC.
Related Content