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PALOMA-3: Subcutaneous Amivantamab + Lazertinib for EGFR+ NSCLC

Video Series

PALOMA-3: Clinical Implications 

Joshua K. Sabari, MD, and Martin Dietrich, MD, PhD, examine both the evolution of first-line EGFR TKIs as standard treatment for EGFR-mutated metastatic non-small cell lung cancer and the ongoing clinical challenges in managing resistance, toxicities, and treatment sequencing in this space.

A panelist discusses how targeted therapies such as EGFR tyrosine kinase inhibitors have become the standard first-line treatment for patients with EGFR-mutated metastatic non–small cell lung cancer, offering improved outcomes compared with traditional chemotherapy.

EGFR mNSCLC Front-Line: Treatment Options

A panelist discusses how managing resistance mechanisms and toxicity profiles and identifying optimal sequencing strategies remain key challenges in treating EGFR-mutated metastatic non–small cell lung cancer despite advances in targeted therapies.

EGFR mNSCLC: Challenges with Treatments in this Space

Panelists discuss how managing adverse events and selecting optimal treatment strategies remain key challenges in front-line EGFR-mutated, non–small cell lung cancer (mNSCLC) therapy, particularly when weighing the efficacy and toxicity profiles of available targeted therapies.

EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

Panelists discuss how PALOMA-3, a phase 3 randomized clinical trial, was designed to evaluate subcutaneous vs intravenous amivantamab, both in combination with lazertinib, in patients with refractory EGFR–mutated non–small cell lung cancer.

PALOMA-3: Study Design and Baseline Characteristics

Panelists discuss how PALOMA-3’s pharmacokinetic and secondary end point analyses demonstrated the clinical benefit of palbociclib through multiple measures, including progression-free survival, objective response rate, and drug concentration levels that inform optimal dosing strategies.

PALOMA-3: Key End Points: Pharmacokinetic and Secondary

Panelists discuss how treatment-emergent adverse events were comparable among patients treated with subcutaneous amivantamab-lazertinib vs intravenous administration in the PALOMA-3 trial.

PALOMA-3: Key Safety Data

Panelists discuss the safety and efficacy data from the phase 3 PALOMA-3 trial, and how they may lead to future considerations of the subcutaneous use of amivantamab with lazertinib in the front line.

PALOMA-3: Managing AEs

Panelists discuss how findings from the phase 3 PALOMA-3 trial of subcutaneous amivantamab plus lazertinib may impact clinical practice, in particular the improvement of patient outcomes and how their preferences will play a role in treatment decisions.

Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

PALOMA-3: Clinical Implications

EP: 1.EGFR mNSCLC Front-Line: Treatment Options

EP: 2.EGFR mNSCLC: Challenges with Treatments in this Space

EP: 3.EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

EP: 4.PALOMA-3: Study Design and Baseline Characteristics

EP: 5.PALOMA-3: Key End Points: Pharmacokinetic and Secondary

EP: 6.PALOMA-3: Key Safety Data

EP: 7.PALOMA-3: Managing AEs

EP: 8.PALOMA-3: Clinical Implications