In this segment the panelist reviews the baseline patient and disease characteristics across the three treatment arms in MARIPOSA-2.
HER3-DXd Yields Activity in NSCLC, Breast Cancer Brain Metastasis Groups
Data from the phase 2 TUXEDO-3 trial support patritumab deruxtecan as a novel treatment option across different cancer populations with brain metastases.
Integrating Dato-DXd Into Early-Line EGFR-Mutant NSCLC Management
Jacob Sands, MD, discussed considerations for EGFR-mutant non–small cell lung cancer following the approval of dato-DXd in this disease.
Zipalertinib Yields Early Activity in EGFR+ NSCLC CNS Metastasis Population
Data from the REZILIENT2 trial show meaningful intracranial activity in patients with NSCLC harboring EGFR exon 20 insertions or other uncommon mutations.
Practice-Changing Lung Cancer Data From the 2025 ASCO Annual Meeting
Stephen Liu, MD; and Joshua Sabari, MD, discuss the most intriguing non–small cell lung cancer and small cell lung cancer breakthroughs from the meeting.
Frontline Immunotherapy Improves OS vs BRAF/MEK Inhibitors in BRAF+ NSCLC
Retrospective cohort findings may inform tailored treatment approaches for frontline metastatic BRAF V600E–mutated non–small cell lung cancer.
Survival Improves With Perioperative Pembrolizumab in Early-Stage NSCLC
Data from the KEYNOTE-671 trial support the use of pembrolizumab among patients with non–small cell lung cancer in the perioperative setting.