Radioactive microspheres benefit liver met pts
CHICAGO-Median overall survival was 13 months among 52 patients who received radioactive microspheres (SIR-Spheres) for colorectal cancer liver metastases after chemotherapy failure. The phase II Italian SITILO study was reported at ASCO 2008 (abstract 4078).
CHICAGO-Median overall survival was 13 months among 52 patients who received radioactive microspheres (SIR-Spheres) for colorectal cancer liver metastases after chemotherapy failure. The phase II Italian SITILO study was reported at ASCO 2008 (abstract 4078).
Clinical benefit was seen in 48% (1 CR, 11 PR, 12 SD). In two patients, liver tumors shrank enough to allow potentially curative surgery to be planned. Among the 24 responders, median survival was 16 months vs 8 months for nonresponders (P = .0006); 40% of responders were alive at 2 years vs none of the nonresponders.
“At a minimum, physicians should consider SIR-Spheres for patients who have liver-only or liver-dominant disease and are failing chemotherapy,” said Prof. Maurizio Cosimelli, of the Regina Elena National Cancer Institute, Rome.
Highlighting Insights From the Marginal Zone Lymphoma Workshop
Clinicians outline the significance of the MZL Workshop, where a gathering of international experts in the field discussed updates in the disease state.
