Risk of transplantrelated mortality doesn’t increase with cord blood

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 18 No 2
Volume 18
Issue 2

This study shows that in patients with acute leukemia, cord blood can be a good alternative,” said Dr. Keating, director of the division of hematology at the University of Toronto.

This study shows that in patients with acute leukemia, cord blood can be a good alternative,” said Dr. Keating, director of the division of hematology at the University of Toronto.

“For stem cell transplants, often there is some urgency, and finding a suitable peripheral blood or bone marrow donor can take a while. The advantage of cord blood is that these cells are typed and cryopreserved, so access to them could be faster.”

In a patient with acute myeloid leukemia in second remission, where time may be important, “it would be appropriate to do a cord blood transplant,” added Dr. Keating, who is also a professor of medicine at the University of Toronto.

Among some physicians, he said, “there may be a perception that using cord blood for stem cell transplants is riskier than peripheral blood or bone marrow sources. Certainly, the immunologic recovery is slowest with cord blood, and patients could thus be more susceptible to infection. But in terms of transplant-related mortality, cord blood is roughly the same when compared with peripheral blood or bone marrow sources.”

Recent Videos
Future findings from a translational analysis of the OVATION-2 trial may corroborate prior clinical data with IMNN-001 in advanced ovarian cancer.
The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
The use of chemotherapy trended towards improved recurrence-free intervals in older patients with high-risk tumors as determined via the MammaPrint assay.
Use of a pharmacist-directed resource appears to improve provider confidence and adverse effect monitoring for patients undergoing infusion therapy.
Reshma L. Mahtani, DO, describes how updates from the DESTINY-Breast09, ASCENT-04, and VERITAC-2 trials may shift practices in the breast cancer field.
2 experts in this video
Related Content