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Study links the risk of ALCL to silicone breast implants

December 2, 2008
Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 17 No 12
Volume 17
Issue 12

Dutch researchers have found an association between anaplastic large T-cell lymphoma and silicone breast implants.

Dutch researchers have found an association between anaplastic large T-cell lymphoma and silicone breast implants.

Daphne de Jong, MD, PhD, from the pathology department at the Netherlands Cancer Institute in Amsterdam, and colleagues performed an individually matched case-control study that included 11 patients with ALCL, five of whom had received bilateral silicone breast implants one to 23 years before their ALCL diagnosis.

Dr. de Jong’s research group noted the presence of 12 diffuse large B-cell lymphomas, including one T-cell-rich B-cell lymphoma; five Burkitt lymphomas; 10 mucosa-associated lymphoid tissue-type lymphomas; three follicular lymphomas; three peripheral T-cell lymphomas; and two indolent B-cell lymphomas, unclassified.

Dr. de Jong and her colleagues determined that the odds ratio for ALCL associated with silicone breast implants was 18.2 (JAMA 300:2030-2035, 2008).

The researchers said, however, that the absolute risk for developing ALCL due to breast implants is low due to the rare occurrence of ALCL. They also said that more studies are needed to confirm their initial findings.

According to the American Society of Aesthetic Plastic Surgeons, there was a 295% increase in the number of women who had breast augmentation between the years 1997 and 2007.

Articles in this issue

Radiology resident compiles staging database
Study links the risk of ALCL to silicone breast implants
CyBorD combo supports stem cell collection in newly diagnosed multiple myeloma
Clara Bloomfield: Buck conventional wisdom always
New breast cancer program reduces time to treatment
PET/CT for prostate ca influences staging, treatment strategy
Racially-based disparities in ca on the rise, not due to smoking
ProStrakan offers patch to prevent nausea and vomiting
Online tool encourages families to bone up on genetics
Bevacizumab plus copper radiotracer shines as imaging probe
Coverting unresectable to resectable: Data still limited
AACR commits to Love/Avon Army of Women
Voters pass end-of-life measure in Washington state
Brachytherapy improves treatment in augmented women
Marathon effort to support cancer care
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