Third-Line Treatment Options for HER2+ mBC after Progression on Trastuzumab Deruxtecan

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Heather McArthur, MD, describes what treatment options she would consider in the third-line setting for HER2+ mBC.

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Administering oral SERD-based regimens may enhance patients’ quality of life when undergoing treatment for ER-positive, HER2-negative breast cancer.
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Gedatolisib-based triplet regimens may be effective among patients with prior endocrine resistance or rapid progression following frontline therapy.
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