Vikram Narayan, MD, on the Future of Nadofaragene Firadenovec and Bladder Cancer

Video

Narayan discusses what he thinks the future of nadofaragene firadenovec and bladder cancer are at this year’s SUO Meeting.

Vikram Narayan, MD, built off of his research at the 21st Annual Meeting of the Society of Urologic Oncology in an interview with CancerNetwork discussing the potential future of nadofaragene firadenovec and the field of bladder cancer.

Transcription:

I think this is a very promising time for patients with bladder cancer, and in particular patients with non-muscle invasive bladder cancer who have failed BCG. When I was a resident in training, I was always struck by how few options we had to offer these patients and fortunately this is something that’s starting to change, and it’s exciting that nadofaragene may be 1 potential option for these patients in the future. There’s still a lot of work that needs to be done, but some of the discussion at SUO was trying to identify ways and sort of develop plans to study biomarkers and other tools to identify which patients will most likely not only do best with certain treatments but potentially even look at combination strategies. And then we’ll also need to study what sequence of treatments, especially as more of these agents become available. What combinations are best and in what order should they potentially be explored for these patients. Those are areas of ongoing research that will need to be delved into.

Recent Videos
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
Despite CD19 CAR T-cell therapy exhibiting efficacy in patients with relapsed/refractory large B-cell lymphoma, less than half achieve long-term remission.
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
Considering which non–muscle-invasive bladder cancer cases may be cured by surgery alone may help mitigate overtreatment in this patient group.
Event-free survival benefit was observed among BCG-naïve patients with carcinoma in situ undergoing treatment with sasanlimab plus BCG.
Related Content