Bladder Cancer

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FDA Approves Adjuvant Durvalumab/Chemo in Muscle-Invasive Bladder Cancer
FDA Approves Adjuvant Durvalumab/Chemo in Muscle-Invasive Bladder Cancer

March 28th 2025

Results from the phase 3 NIAGARA trial led to the approval of adjuvant durvalumab/chemotherapy for patients with muscle-invasive bladder cancer after radical cystectomy.

No grade 3 or higher treatment-related adverse effects or deaths were reported among those with non-muscle invasive bladder cancer in the BOND-003 trial.
Cretostimogene Grenadenorepvec Yields Sustained Antitumor Activity in NMIBC

March 25th 2025

UGN-102 Yields Enduring 18-Month Responses in Low-Grade NMIBC
UGN-102 Yields Enduring 18-Month Responses in Low-Grade NMIBC

March 11th 2025

Antihistamines Added to IO Associated with Longer Survival in Urothelial Carcinoma
Antihistamines Added to IO Associated with Longer Survival in Urothelial Carcinoma

March 4th 2025

Outcomes observed in the phase 3 EV-302 trial are “transformative” for most patients with advanced or metastatic urothelial carcinoma.
EV-302 Supports Enfortumab Vedotin Plus Pembrolizumab as Bladder Cancer SOC

February 25th 2025

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Solitary Extramedullary Plasmacytoma of the Bladder

August 15th 2010

Plasmacytoma is a rare B-lymphocyte neoplastic disorder that usually presents as the generalized disease multiple myeloma. Less than 5% of the cases present as a solitary mass of monoclonal plasma cells in the bone or soft tissue. Although solitary extramedullary plasmacytoma (SEP) may arise in any organ, it rarely involves the urinary bladder. A 67-year-old male without a history of multiple myeloma presented with urinary frequency and nocturia; he was later diagnosed with SEP of the bladder. The patient was initially treated with a course of radiation therapy without symptomatic improvement; therefore a chemotherapy regimen consisting of lenalidomide and dexamethasone was subsequently given for six cycles. SEP usually carries a better prognosis and higher cure rate than solitary plasmacytoma of bone, as SEP is radiation sensitive. The role of adjuvant chemotherapy in the treatment of SEP that is resistant to radiation therapy is not clear, since most of the recommendations have been derived from the experience of head and neck SEP. The literature also lacks recommendations for choice of a chemotherapy regimen and surveillance of isolated bladder plasmacytoma. Here we present the first case of a radiation-resistant solitary plasmacytoma of the bladder that was successfully treated with lenalidomide and dexamethasone with successful clinical remission.