48 Prevalence of “HER2 Ultra-Low” Among Advanced Breast Cancer Patients With Historical IHC0 Status
Neoadjuvant SCRT Combo May Prolong Survival in Advanced Rectal Cancer
Among patients with rectal cancer who underwent total mesorectal excision following SCRT plus camrelizumab and chemotherapy, the 3-year OS rate was 93.3%.
Camrelizumab/Apatinib Plus Chemotherapy May Show Promise in ES-SCLC
The safety profile of camrelizumab plus apatinib and chemotherapy in a phase 1 study aligns with prior reports of each agent.
Advancing Research, Novel Technologies to Deliver Exceptional Cancer Care
The Jack & Sheryl Morris Cancer Center offers “state-of-the-art” surgical suites and advanced radiation technology, says Andrew M. Evens, DO, MBA, MSc.
49 Clinical Characteristics and Treatment Persistence in US Patients With HR+/HER2–, Node-Positive Early Breast Cancer Treated With Abemaciclib: Real-World Study From First Year After Approval
Navigating the Landscape of PSMA PET Imaging Agents in Prostate Cancer
Prostate-specific membrane antigen PET imaging has completely altered the landscape of prostate cancer detection and management. Read as several experts discuss the trajectory and growth of these agents.
Chemoimmunotherapy Boosts Pathological Complete Responses in MIBC
Real-world data may support chemotherapy plus immune checkpoint blockade as a promising frontline neoadjuvant therapy for muscle-invasive bladder cancer.
Identifying the Treatment Landscape for Advanced Lung Cancers
Thoracic surgeon, Ankit Bharat, MBBS, discussed surgical strategies among patients with advanced lung cancer diagnoses based on staging.
CHMP Recommends Approval of Belantamab Mafodotin Combos in Multiple Myeloma
The European Commission is expected to approve the belantamab mafodotin combinations for this multiple myeloma population in the third quarter of 2025.
52 Correlation and Prediction of Complete Pathologic Response Rates and Ki-67 in Patients Receiving Neoadjuvant Immunotherapy for Triple-Negative Breast Cancer
CHMP Recommends Mirdametinib for EU Approval in Adult/Pediatric NF1-PN
The EMA’s CHMP has adopted a positive opinion for mirdametinib in patients with inoperable plexiform neurofibromas of neurofibromatosis type 1.
Highlighting the DREAM Program for Late-Stage Lung Cancer Treatment
In a CancerNetwork® YouTube video, Cornelia Tischmacher, a mother of twins from Germany, outlined her receipt of double lung transplantation.
ASCO 2025: The Presentations That May Shift the Cancer Care Paradigm
From breast cancer to head and neck tumors, the 2025 ASCO Annual Meeting may feature a wide range of practice-changing data across cancer care.
Obe-Cel Receives Positive CHMP Opinion for R/R B-Cell ALL
The positive CHMP opinion is based on results from the phase 1b/2 FELIX trial evaluating obe-cel in relapsed/refractory B-cell ALL.
Pulsed Electric Field Ablation May Show Feasibility, Safety in Early NSCLC
Data from the INCITE-ES study show 100% technical success with pulsed electric field energy delivery before surgical resection.
AI Transforms HER2-Low, HER2-Ultralow Breast Cancer Diagnostics for Pathologists
AI-assisted training dramatically reduced HER2-null overscoring and improved sensitivity in HER2-low and HER2-ultralow breast cancer cases.
53 Comparison of Surgical Complications With Direct-to-Implant vs Tissue Expander Reconstruction After Wise Pattern Skin-Sparing Mastectomy
Frontline Lurbinectedin Plus Atezolizumab Enhances Survival in ES-SCLC
The phase 3 IMforte trial evaluating lurbinectedin plus atezolizumab is the first to show PFS and OS improvement with first-line maintenance for ES-SCLC.
Inavolisib Combo Significantly Extends Survival in PIK3CA+ Breast Cancer
Final OS data from INAVO120 demonstrate, for the first time, a significant OS improvement with a PI3K-targeted agent in this breast cancer population.
GLP-1 Use Not Linked to Increased Obesity-Related Cancer Rates
There was a 7% lower incidence of obesity-related cancer with GLP-1 receptor agonist use.
Efficacy Data Support Nivolumab/Ipilimumab as First-Line HCC Treatment
Survival and safety data from the phase 3 CheckMate 9DW trial showed that nivolumab plus ipilimumab was superior to lenvatinib or sorafenib in advanced HCC.
China’s NMPA Approves Tafasitamab/Lenalidomide in ASCT-Ineligible DLBCL
Tafasitamab is the first CD19 antibody approved in China for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma.
Trial Insights from TROPiCS-02 and DESTINY-Breast06 in HR+/HER2– Breast Cancer
Kit Yu Lu, MD, discussed the implications of the TROPiCS-02 and DESTINY-Breast06 trial data for sequencing ADCs in HR+/HER2– breast cancer.
The Radiation Oncology Perspective: Genomic vs Genetic Testing in Prostate Cancer
Decipher Prostate, Oncotype DX, and Prolaris are 3 gene expression testing options for patients with prostate cancers. Read as experts discuss them.
ODAC Votes 8-to-0 Against First-Line Talazoparib/Enzalutamide in mCRPC
Eight votes were cast against the favorability of talazoparib and enzalutamide in the first-line setting for patients with metastatic castration-resistant prostate cancer.
54 The Treatment of Breast Cancer With Percutaneous Thermal Ablation: Results of the THERMAC Trial
Exploring First-Line ALK Inhibitors, TKI Sequencing in ALK-Positive NSCLC
Given an unmet need for efficacious therapies against ALK-positive NSCLC, experts discuss optimal ALK TKI sequencing for patients with this disease.
Meeting With FDA “Successful” Regarding PT-112 in mCRPC
Following a positive meeting with the FDA, PT-112 is set to advance to a phase 3 trial for patients with metastatic castration-resistant prostate cancer.
FDA ODAC Votes 5-to-4 Against UGN-102 Intravesical Solution for Bladder Cancer
ODAC has voted against the use of UGN-102 intravesical solution for patients with advanced bladder cancer.
Comparing ADCs in HR+/HER2– Breast Cancer Without Head-to-Head Trials
Currently, sacituzumab govitecan, T-DXd, and Dato-DXd cannot be compared in HR+/HER2– breast cancer due to a lack of head-to-head trials.