Defining the Role of Perioperative Therapy Across Lung Cancer Subtypes
Patients with lung cancer who achieve a complete response with neoadjuvant therapy may not experience additional benefit with adjuvant immunotherapy.
Novel Immunotherapy Achieves Responses/RFS in High-Risk, BCG-Unresponsive NMIBC
The intravesical MVR-T3911 treatment did not lead to any dose-limiting toxicities in patients with high-risk, BCG-unresponsive non-muscle invasive bladder cancer.
Ibrutinib/Venetoclax Yields Long-Term Efficacy in Japanese R/R MCL Trial
Over 80% of a small cohort of patients with mantle cell lymphoma achieved a complete response to ibrutinib plus venetoclax.
FDA and EMA Clear Phase 3 POLARIS-1 Trial in Newly Diagnosed Ph+ ALL
Olverembatinib plus low-intensity chemotherapy achieved an MRD-negativity rate in about 65% of patients with newly diagnosed Ph+ ALL.
Nadunolimab Exhibits Comparable Efficacy Vs Chemotherapy Alone in TNBC
The safety profile of nadunolimab in patients with triple-negative breast cancer was consistent with its known profile, and no significant signals emerged.
Outlining Emergent Research in the EGFR-Mutated Lung Cancer Space
Numerous trials have displayed the evolution of EGFR inhibition alone or with chemotherapy/radiation in the EGFR-mutated lung cancer space.
Why Survivorship Matters: Creating Space in Multidisciplinary Cancer Care
Oncology care requires psychosocial support, nutrition, and survivorship, which can result in improved patient outcomes and quality of life.
FDA Approves Liso-Cel in Marginal Zone Lymphoma After 2 Lines of Therapy
Treatment with liso-cel led to complete responses in 55.8% of patients with marginal zone lymphoma who received at least 2 prior lines of systemic therapy.
ASH 2025: Key Anticipated Updates in the Leukemia Landscape
Updated results at ASH 2025 may support new alternatives to continuous therapy and standard intensive chemotherapy across different leukemia types.
ASH 2025: Which Presentations Will Move the Multiple Myeloma Needle?
From phase 3 trial updates to results on trispecific antibodies, ASH 2025 may feature a variety of practice-shifting presentations across multiple myeloma.
How to Manage Oligometastatic Kidney Cancer? Insights From IKCS 2025
Experts highlight considerations for treating patients with oligometastatic kidney cancer, such as differentiating between de novo and recurrent disease.
Silevertinib Displays Robust Antitumor Activity in EGFR-Mutated NSCLC
Developers have outlined plans to initiate a randomized phase 2 trial evaluating silevertinib in patients with newly diagnosed glioblastoma.
Differences in Clinical Trial Availability vs Distribution of Disease Among Gynecological Cancers
Elucidating Common Toxicities Observed with Immunotherapies in SCLC
Although high grade adverse effects are infrequent among patients undergoing treatment for SCLC, CRS and ICANS may occur in higher frequencies.
Novel Cancer Vaccine Improves OS vs SOC in Newly Diagnosed GBM
Treatment with IGV-001 demonstrated a 45% increase in overall survival compared with standard of care in patients with newly diagnosed glioblastoma.
Laparoscopic Distal Gastrectomy Appears Feasible in T4a Gastric Cancer
Qualified surgeons may offer laparoscopic distal gastrectomy as an alternative to open distal gastrectomy among those with clinical T4a gastric cancer.
The Show and After Show Previews the 2025 ASH Annual Meeting
Co-hosts Kristie L. Kahl and Andrew Svonavec highlight what to look forward to at the 67th Annual ASH Meeting in Orlando.
Delving Into the Current State of Clinical Practice in SCLC
In a spotlight session at the Chemotherapy Foundation Symposium, Anne Chiang, MD, PhD, covered developments in the field of LS-SCLC.
Investigational Cell Therapy Yields Durable Complete Response in BCG-Naïve NMIBC
During treatment with TARA-002, there were no grade 3 or higher TRAEs, and TRAEs did not lead to any treatment discontinuations in patients with BCG-naïve NMIBC.
FDA Gives Traditional Approval to Pirtobrutinib in CLL/SLL
Data from the BRUIN-CLL-321 trial led to the FDA granting traditional approval to pirtobrutinib in CLL/SLL indications.
FDA Selects Detalimogene for Manufacturing Pilot Program in NMIBC
A 6-month CR rate of 62% was observed with detalimogene voraplasmid in treating patients with BCG-unresponsive non–muscle invasive bladder cancer.
The Role of Artificial Intelligence in Palliative Oncology: Zeroing in on Hematologic Malignancies
AI revolutionizes palliative oncology by enhancing prognostication, symptom management, and personalized care for patients with hematologic malignancies.
Cooperative Trial Aims to Bring Precision Medicine to SCLC Subgroups
Based on a patient’s SCLC subtype, and Schlafen 11 status, patients will be randomly assigned to receive durvalumab alone or with a targeted therapy in the S2409 PRISM trial.
FDA Grants Fast Track Designation to Novel FLT3/CD3 Bispecific in R/R AML
Phase 1 data related to CLN-049 for patients with acute myeloid leukemia will be presented at the 2025 ASH Annual Meeting and Exposition.
Discussing the Immune System and Improving Outcomes in AML
Daniel Peters, MD, aims to reduce the toxicity associated with AML treatments while also improving therapeutic outcomes.
FDA Approves Novel Blood-Based Prostate Cancer Test for Elevated PSA Levels
Data from a prospective study showed that the IsoPSA prostate cancer test outperformed total PSA and free PSA in men 50 years or older with elevated PSA.
JANX007 Displays Encouraging Safety/Efficacy in Metastatic CRPC
Results from the phase 1b ENGAGER-PSMA-01 trial showed deep PSA reductions and a favorable CRS profile among patients with taxane-naive CRPC.
Outlining the Impact of Immunochemotherapy in First-Line SCLC Subtypes
Findings from numerous clinical trials vindicating the addition of immunotherapy to first-line chemotherapy in SCLC have emerged over the past several years.
A Decline in the US Oncology Workforce: What Will the Next Decade Bring?
Rising cancer diagnoses in the US highlight urgent needs for improved oncology education, workforce distribution, and care infrastructure, especially in rural areas.
What Adverse Effects May Occur During Acute Myeloid Leukemia Treatment?
Patients with AML will experience different toxicities based on the treatment they receive, whether it is intensive chemotherapy or targeted therapy.