Psychosocial Cancer Care Has Direct Ties to QOL, Emotional Well-Being
Organizations such as ASCO and ESMO recognize the importance of integrating psychosocial care into cancer treatment.
Durvalumab Combo Shows Encouraging Preliminary Data in High-Risk UTUC
Combining durvalumab with chemotherapy produced a good safety profile without increasing surgical risk in the phase 2 iNDUCT-GETUG V08 trial.
Neoantigen-Specific TIL/Pembrolizumab Elicits Responses in GI Cancers
A phase 2 study found that treatment with tumor-infiltrating lymphocytes elicited a partial response rate of 15.1% in patients with gastrointestinal cancers.
FDA Approves Nivolumab/Ipilimumab in Adult/Pediatric MSI-H or dMMR CRC
The FDA approved nivolumab with ipilimumab in adult and pediatric patients with CRC based on data from the phase 3 CHECKMATE-8HW trial.
PENELOPE-B Trial Shows Mixed Palbociclib Results in Breast Cancer Subtypes
Palbociclib with endocrine therapy did not improve outcomes in hormone receptor–positive, HER2-negative breast cancer but improved invasive DFS in lobular disease.
Optimizing Radiotherapy QOL for Advanced Prostate Cancer Populations
Focused, high-dose radiotherapy doses may prolong survival and the interval to subsequent therapy for patients with advanced prostate cancer.
Surufatinib/Toripalimab Shows Encouraging Activity in NSCLC and SCLC
Surufatinib/toripalimab elicited an ORR of 57.1% in patients with treatment-naïve NSCLC and 15.8% in patients with pretreated SCLC in a phase 2 trial.
ESMO Develops Molecular Tumor Boards Guidelines to Standardize Practice
The ESMO Precision Oncology Working Group recommendations can serve as guidance to define standards for MTBs to integrate precision oncology into practice.
Mitigating Proton Beam Therapy Disparities for Different Cancer Populations
Data show increasing use of proton therapy overall but widening gaps in populations who have access to this treatment, Curtiland Deville Jr, MD, says.
Considerations for TKI Selection and Sequencing in ALK-Positive NSCLC
Patients with ALK-positive NSCLC not vulnerable to neurological adverse effects or prone to weight issues, might benefit from treatment with lorlatinib.
Once-Weekly Doses of Carfilzomib Show Balanced Benefit in Real-World RRMM
A real-world analysis showed that 56 mg/m2 of carfilzomib once weekly offered many benefits over 56 mg/m2 twice weekly and 70 mg/m2 once weekly in myeloma.
Data Show Underutilization of Appendectomy in Appendix Cancer Population
A lack of guidelines, a loss of follow-up, and out-of-state procedures are all potential reasons for 26% of patients undergoing appendectomy.
Elevating the Quality of Cancer Care via Cross-Department Collaboration
Experts from Sibley Memorial Hospital discuss how multidisciplinary work has enhanced outcomes such as survival and resource use at their institution.
Belzutifan Improves Disease-Specific Symptoms/QOL vs Everolimus in RCC
Time to deterioration in physical functioning and role functioning was similar among those receiving belzutifan vs everolimus for renal cell carcinoma.
Novel Treatments May Have the Potential to Impact GI Cancer Care
Treatment with KRAS inhibitors may help mitigate a common driver of genetic alteration across a majority of pancreatic cancers.
Making a ‘World of Difference’ Via Multidisciplinary Care in GI, GU Cancers
Various methods of communication ensure that members from radiation oncology, pathology, and other departments are on the same page regarding treatment.
Active Surveillance Shows Noninferior OS vs Surgery in Esophageal Cancer
Postoperative complications and mortality after standard or postponed surgery for esophageal cancer after active surveillance were similar in both groups.
Staged Colectomy May Be Preferable to Upfront Colectomy in Appendix Cancer
The staged approach to colectomy offers survival benefits, and it may help avoid unnecessary procedures that only require appendectomy.
Reviewing QOL Strategies/Considerations Following Bladder Cancer Surgery
Comprehensive prehabilitation may help prepare patients for bladder-preserving surgery, helping to optimize quality of life outcomes.
CRC Yields Most Prevalent Data at Recent GI Meeting
Updated results from the BREAKWATER study seemed to be most impactful to the CRC space, according to Michael J. Pishvaian, MD, PhD.
No Subgroups Benefit From HIPEC/CRS in Colorectal Peritoneal Metastasis
“We did not find any benefit for any of the subgroups in our paper and our study,” Muhammad Talha Waheed, MD, stated.
EC Approves T-DXd Monotherapy in HR+, HER2-Low/Ultralow Breast Cancer
Results from the phase 3 DESTINY-Breast06 trial demonstrated that trastuzumab deruxtecan (T-DXd) monotherapy improved progression-free survival over chemotherapy in patients with breast cancer.
Tovecimig Yields Significant Responses in Advanced Biliary Tract Cancer
The prespecified number of events required to undergo analyses of the secondary end points, including PFS, OS, and DOR, have not been met.
DecisionDx-Melanoma Test Accurately Identifies Low-Risk SLN Positivity
All patients identified as low risk for sentinel lymph node positivity with the DecisionDx-Melanoma test had recurrence-free status after 3 years.
Outlining Risk Factor Identification and Mitigation in Bladder Cancer
Ongoing research suggests environmental exposures and the role of microbiomes may influence bladder cancer development and response to treatment.
HIPEC/CRS Confers No Benefit, Adds Risk in Colorectal Peritoneal Metastases
Adding HIPEC to CRS did not show any added benefit but has shown increased toxicities in patients with colorectal peritoneal metastasis.
The Importance of Multidisciplinary Care in Bone Marrow Transplantation
Multidisciplinary care is important for all cancer care, specifically bone marrow transplant, stated Nina Wagner-Johnston, MD.
Telehealth Groups May Improve the Social Lives of Young Cancer Populations
Most patients with cancer who took part in a telehealth group expressed that they liked the members of their group and felt less social isolation.
Developers Terminate Clinical Program for Ociperlimab in Lung Cancer
A futility analysis showed that ociperlimab was unlikely to reach the primary end point of overall survival as part of the phase 3 AdvanTIG-302 trial.
Ensuring Ancillary Care Access to Bolster QOL in Pancreatic Cancer
Providing easier access to ancillary services for patients with PDAC who live farther away from the treatment center may help them complete the treatment regimen.