Panelists discuss how the treatment landscape for EGFR-mutated lung cancer has evolved, with 3 strong options now available, including single-agent osimertinib and 2 combinations: osimertinib plus chemotherapy (FLAURA2) and amivantamab plus lazertinib (MARIPOSA), with the latter showing significant overall survival benefits.
Video content above is prompted by the following:
First-Line EGFRm NSCLC Treatment Landscape Overview
Current Treatment Options
The treatment landscape for EGFR-mutated (EGFRm) non–small cell lung cancer (NSCLC) has evolved significantly, with 3 strong first-line options now available:
Recent Advances: MARIPOSA Trial Results
The MARIPOSA trial, a randomized phase 3 study, compared 3 treatment regimens:
Key Findings:
The amivantamab plus lazertinib combination represents a novel mechanism targeting both EGFR and c-MET receptors, providing a valuable new option for first-line treatment of EGFRm NSCLC.
The trial continues with follow-up for a 5-year landmark analysis, with current survival projections suggesting beyond 4 years of median OS for patients receiving the combination therapy.
Prolaris in Practice: Guiding ADT Benefits, Clinical Application, and Expert Insights From ACRO 2025
April 15th 2025Steven E. Finkelstein, MD, DABR, FACRO discuses how Prolaris distinguishes itself from other genomic biomarker platforms by providing uniquely actionable clinical information that quantifies the absolute benefit of androgen deprivation therapy when added to radiation therapy, offering clinicians a more precise tool for personalizing prostate cancer treatment strategies.
CCR Scores and Beyond: Precision Strategies for Treatment Intensification in Prostate Cancer
April 15th 2025Alvaro Martinez, MD discusses how emerging genomic risk stratification tools such as the clinical cell-cycle risk (CCR) score are transforming personalized prostate cancer treatment by enabling more nuanced assessments of metastasis risk and treatment intensification strategies beyond traditional NCCN risk groupings.