Panelists discuss how the significant overall survival (OS) benefit demonstrated by the new combination therapy (amivantamab-lazertinib) compared with standard monotherapy makes it a preferred treatment option for most patients despite a slightly increased toxicity and time commitment.
Video content above is prompted by the following:
MARIPOSA Trial Results for EGFRm NSCLC Treatment
OS Data for Amivantamab-Lazertinib vs Osimertinib
The MARIPOSA trial demonstrates a significant OS benefit for the amivantamab-lazertinib combination compared with osimertinib monotherapy:
Impact on First-Line Treatment Approach
Conclusion
The consensus among the panelists is that OS is the paramount end point for most patients, particularly younger ones, and this combination therapy delivers meaningfully on this metric.
Prolaris in Practice: Guiding ADT Benefits, Clinical Application, and Expert Insights From ACRO 2025
April 15th 2025Steven E. Finkelstein, MD, DABR, FACRO discuses how Prolaris distinguishes itself from other genomic biomarker platforms by providing uniquely actionable clinical information that quantifies the absolute benefit of androgen deprivation therapy when added to radiation therapy, offering clinicians a more precise tool for personalizing prostate cancer treatment strategies.
CCR Scores and Beyond: Precision Strategies for Treatment Intensification in Prostate Cancer
April 15th 2025Alvaro Martinez, MD discusses how emerging genomic risk stratification tools such as the clinical cell-cycle risk (CCR) score are transforming personalized prostate cancer treatment by enabling more nuanced assessments of metastasis risk and treatment intensification strategies beyond traditional NCCN risk groupings.