CAR T-Cell Therapy in R/R MM: Treatment Selection, Safety, and Future Perspectives
Myeloma specialists have a comprehensive discussion on CAR T-cell therapy, highlighting treatment selection considerations, adverse event management strategies, unmet needs, and ongoing research.
EP: 1.The Rationale for CAR T-Cell Therapy in Relapsed/Refractory Multiple Myeloma
EP: 2.The Impact of CAR T-Cell Therapy on Relapsed/Refractory MM Treatment
EP: 3.How CAR T-Cell Therapy Impacts Relapsed/Refractory MM Treatment
EP: 4.Key Takeaways from the CARTITUDE-1 and KarMMa Studies
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EP: 5.CAR T-Cell Therapy in R/R MM: Treatment Selection, Safety, and Future Perspectives
EP: 6.Insights from CARTITUDE-4 and KarMMa-3 in R/R MM
EP: 7.Future Perspectives on CAR T-Cell Therapy in Relapsed/Refractory MM
Video content above is prompted by the following questions:
- Can you describe the ideal patient to receive cilta-cel vs ide-cel?
- In which patient populations would you not choose to give cilta-cel? Ide-cel?
- What is the role of patient preferences and shared decision-making when choosing between cilta-cel and ide-cel?
- How does the safety profile factor into your treatment choice?
- What are the some commonly observed toxicities with CAR T-cell therapy?
- What are some strategies used to manage adverse events?
- What are some challenges or barriers seen with CAR T-cell therapy?
- What are the logistical challenges associated with CAR T-cell therapy and what are the potential solutions?
- What is the future of CAR T-cell therapy in relapsed/refractory multiple myeloma (R/R MM)?
- Please highlight any other trials of note investigating the use of cilta-cel or ide-cel for R/R MM.
- What other targets or dual targets are being investigated? (GPRC5D, CD19, BCMA, etc)
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![“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fcancernetwork%2F70a5f0fed7009863fe30cf0740cf32014ebaf5be-2974x1660.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 "“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.")
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Navigating AE Management for Cellular Therapy Across Hematologic Cancers
Tiba Al Sagheer, PharmD, BCOP, BCACP;Rebecca Gonzalez, PharmD, BCOP, FASTCT;Syeda Saba Kareem PharmD, BCOP
August 11th 2025Podcast
A panel of clinical pharmacists discussed strategies for mitigating toxicities across different multiple myeloma, lymphoma, and leukemia populations.
