Jason Luke, MD, Discusses Advancement of Immunotherapy For Metastatic Disease at 2021 ESMO

News
Video

CancerNetwork® sat down with Jason Luke, MD, at the 2021 European Society for Medical Oncology Congress to talk about the latest developments in the use of immunotherapy for metastatic disease.

At the 2021 European Society of Medical Oncology Congress, CancerNetwork® spoke with Jason Luke, MD, of the University of Pittsburgh Medical Center, about advancements in immunotherapy that he’s excited about and how they may improve outcomes in patients living with metastatic disease. 

Transcript:

Across oncology, I think what’s exciting is a two-fold advancement in immunotherapy. One [area of advancement] is adjuvant clinical trials where we’re starting to apply immunotherapies to avoid metastatic disease altogether. Given the safety profile of checkpoint blockade, I’m really excited about that and that will lead to an improvement in the long term in terms of reduction in metastatic burden.

The other side of it is there’s a lot of developmental immunotherapies that are being developed. Those are new drug targets, as well as novel engineering approaches of immunotherapies. I’m really excited also about that next generation of immunotherapies that are coming along, to expand the utility of immunotherapy and reduce our reliance to chemotherapy over many lines of treatment for metastatic disease.

Recent Videos
Elucidating nonresponses to bispecific T-cell engagers may be an important research consideration in the multiple myeloma field.
Barriers to access and financial toxicities are challenges that must be addressed for CAR T-cell therapies in LBCL, according to Jose Sandoval Sus, MD.
Fixed treatment durations with bispecific antibodies followed by observation may help in mitigating infection-related AEs, according to Shebli Atrash, MD.
Epistemic closure, broad-scale distribution, and insurance companies are the 3 largest obstacles to implementing new peritoneal surface malignancy care guidelines into practice.
Shebli Atrash, MD, stated that MRD should be considered carefully as an end point, given potential recurrence despite MRD negativity.
“This is something where this is written by the trainees, for the trainees, and, of course, for all the other clinicians who take care of patients,” said Kiran Turaga, MD, MPH.
Data from the phase 3 DeLLphi-304 trial at ASCO 2025 revealed a survival advantage with tarlatamab vs chemotherapy in second-line ES-SCLC.
The FDA approval of tarlatamab in SCLC has received much press attention, according to Daniel R. Carrizosa, MD, MS.
These new guidelines aim to alleviate some of the problems caused by patients with peritoneal metastases being diagnosed with the disease in late stages.
The National ICE-T Conference may inspire future collaboration between community and academic oncologists in the management of different cancers.
Related Content