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Updates in the Treatment of Advanced RCC: Highlights from ASCO GU 2024 : Episode 6

Managing Immune-Related Toxicities with Frontline RCC Therapies

March 12, 2024
By Elizabeth Plimack, MD
Benjamin L. Maughan, MD, PharmD
  • Martin H. Voss, MD

Opinion
Video

Expert panelists discuss the importance of rapid improvement within 24-72 hours with steroids for managing unpredictable immune-related toxicities that can occur with frontline IO-IO or IO-TKI regimens for patients with RCC.

EP: 1.Long Term Follow Up Data From Checkmate 214 on Nivolumab Plus Ipilimumab in First Line Clear Cell RCC

EP: 2.Subgroup Analysis from CLEAR Trial: Efficacy Outcomes by Baseline Tumor Size in Treatment of Metastatic Clear Cell RCC

EP: 3.Network Meta-Analysis Comparing Efficacy of Lenvatinib Plus Pembrolizumab to Other First Line Treatments for Metastatic Clear Cell RCC

EP: 4.Frontline Treatment Approaches for Advanced Clear Cell RCC

EP: 5.Treatment Decisions for Favorable Risk RCC

Now Viewing

EP: 6.Managing Immune-Related Toxicities with Frontline RCC Therapies

EP: 7.Treating Patients with RCC and Brain, Liver, or Bone Metastases

EP: 8.Frontline Therapy for Patients With Non-Clear Cell RCC

EP: 9.Non-Clear Cell RCC: Key Learnings and Future Research Directions

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Efficacy and safety outcomes in the phase 3 CONTACT-03 study were consistent regardless of prior immunotherapy or tyrosine kinase inhibitor use.

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Adverse reactions in the phase 3 ENVISION trial were largely mild to moderate in severity, and serious reactions occurred in 12% of those with NMIBC.

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Adverse reactions in the phase 3 ENVISION trial were largely mild to moderate in severity, and serious reactions occurred in 12% of those with NMIBC.


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A machine learning-based approach found that evaluating multiple biomarker features may identify outcomes and treatment resistance in renal cell carcinoma.


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Eight votes were cast against the favorability of talazoparib and enzalutamide in the first-line setting for patients with metastatic castration-resistant prostate cancer.

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