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Updates in the Treatment of Advanced RCC: Highlights from ASCO GU 2024 : Episode 6

Managing Immune-Related Toxicities with Frontline RCC Therapies

March 12, 2024
By Elizabeth Plimack, MD
Benjamin L. Maughan, MD, PharmD
  • Martin H. Voss, MD

Opinion
Video

Expert panelists discuss the importance of rapid improvement within 24-72 hours with steroids for managing unpredictable immune-related toxicities that can occur with frontline IO-IO or IO-TKI regimens for patients with RCC.

EP: 1.Long Term Follow Up Data From Checkmate 214 on Nivolumab Plus Ipilimumab in First Line Clear Cell RCC

EP: 2.Subgroup Analysis from CLEAR Trial: Efficacy Outcomes by Baseline Tumor Size in Treatment of Metastatic Clear Cell RCC

EP: 3.Network Meta-Analysis Comparing Efficacy of Lenvatinib Plus Pembrolizumab to Other First Line Treatments for Metastatic Clear Cell RCC

EP: 4.Frontline Treatment Approaches for Advanced Clear Cell RCC

EP: 5.Treatment Decisions for Favorable Risk RCC

Now Viewing

EP: 6.Managing Immune-Related Toxicities with Frontline RCC Therapies

EP: 7.Treating Patients with RCC and Brain, Liver, or Bone Metastases

EP: 8.Frontline Therapy for Patients With Non-Clear Cell RCC

EP: 9.Non-Clear Cell RCC: Key Learnings and Future Research Directions

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The FDA did not expand the indication to include patients with non-homologous recombination-repair gene-mutated castration-resistant prostate cancer.

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The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.

CAN-2409/EBRT Improves Disease-Free Survival in Localized Prostate Cancer

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The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.


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Eight votes were cast against the favorability of talazoparib and enzalutamide in the first-line setting for patients with metastatic castration-resistant prostate cancer.


Data from the LITESPARK-015 trial supported the FDA’s decision to approve belzutifan monotherapy in patients with advanced, unresectable, or metastatic PPGL.

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Data from the LITESPARK-015 trial supported the FDA’s decision to approve belzutifan monotherapy in patients with advanced, unresectable, or metastatic PPGL.

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