The panel discusses key learnings from recent studies in non-clear cell RCC subtypes and the need to better understand disease biology to develop optimized, histology-specific therapies rather than extrapolating clear cell treatment approaches.
UGN-103 Exhibits Durable Responses in Recurrent LG-IR-NMIBC
The FDA agreed that data from the UTOPIA trial, with UGN-103 demonstrating a 77.8% 3-month CR rate in patients with LG-IR-NMIBC, support an NDA submission.
What Were The Most Impactful GU Oncology Data From ESMO 2025?
Experts highlight the top 5 presentations from ESMO 2025 that may have long-term clinical implications for genitourinary cancer management.
177Lu-PSMA-I&T/223Ra Display Safety and Feasibility in Metastatic CRPC
The PSA response rate and radiographic PFS were similar with the 177Lu-based combination regimen vs the radiotracer alone in metastatic CRPC.
Exploring the ESMO 2025 Presentations That May Shift GU Oncology
Experts highlight anticipated sessions at the 2025 ESMO Congress, including those on the PSMAddition and EV-303 trials.
Belzutifan Plus Lenvatinib Improves PFS/ORR in Advanced Pretreated RCC
Belzutifan/lenvatinib also showed a favorable trend toward improvement for overall survival in this advanced renal cell carcinoma population.
FDA Grants Priority Review to Enfortumab Vedotin Combo in MIBC Subset
Enfortumab vedotin plus pembrolizumab before and after surgery improved EFS vs surgery alone in patients with MIBC in the phase 3 EV-303 trial.