MM Treatment: CAR T-Cell Therapy Selection and Insurance Considerations

Opinion
Video

The panel discusses the utilization of CAR T-cell therapy for patients with multiple myeloma, highlighting treatment selection, sequencing, and insurance considerations.

Video content above is prompted by the following questions:

  • How might you consider sequencing therapies for this patient? Please describe how you would approach treating this patient in your practice.
    • What factors impact your decision?
    • How do you incorporate patient preferences and quality of life considerations into the discussion when determining the sequencing of bispecifics and CAR T-cell therapy in R/R MM?
  • Can BCMA-targeting bispecifics be used in patients who have received prior BCMA targeting CAR-T therapies?
    • Might you consider a different target?
  • Might your strategy differ if the patient had received ide-cel instead of cilta-cel?
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“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.
Barry Paul, MD, listed cilta-cel, anito-cel, and arlo-cel as 3 of the CAR T-cell therapies with the most promising efficacy in patients with multiple myeloma.
Elucidating nonresponses to bispecific T-cell engagers may be an important research consideration in the multiple myeloma field.
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