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Optimizing Treatment for Patients with Relapsed/Refractory Multiple Myeloma : Episode 2

Navigating Treatment Advancements and Recent Approvals in R/R Multiple Myeloma: Expert Insights

June 28, 2024
By Rafael Fonseca, MD
Samer A. Al'Hadidi, MD
  • Naresh Bumma, MD
  • Hans Lee, MD

Opinion
Video

Focusing on recent approvals in earlier lines of relapsed/refractory multiple myeloma, the panel has a comprehensive discussion on the CARTITUDE-4 and KarMMa-3 studies and shares clinical insights on administering CAR T-cell therapy and monitoring patients.

EP: 1.Advancements in the Treatment of Newly Diagnosed MM: Updates from the Phase 3 IMROZ Study

Now Viewing

EP: 2.Navigating Treatment Advancements and Recent Approvals in R/R Multiple Myeloma: Expert Insights

EP: 3.Updates From the Phase 2 MonumenTAL-2 Study Investigating Talquetamab in R/R MM

EP: 4.Long-Term Follow-up with Teclistamab in R/R MM: Updates from MajesTEC-1

EP: 5.Treatment Strategies with Elranatamab in R/R MM: Updates from the MagnetisMM Trials

EP: 6.Expert Perspectives: Sequencing Approaches with CAR-T and Bispecifics in R/R MM

EP: 7.Expert Insights: Strategies for Step-Up Dosing and Long-Term Treatment Management with Bispecifics in R/R MM

EP: 8.The Role of MRD Testing in Guiding Treatment in R/R MM: ASCO 2024 Updates from PERSEUS

EP: 9.Considerations in Sequencing BCMA-Targeting Bispecifics and CAR-T Therapies in R/R MM

EP: 10.Cilta-cel in R/R MM: ASCO 2024 Updates from CARTITUDE Trials

EP: 11.AE Management for CAR-T Therapy: Expert Insights and Perspectives

EP: 12.Looking Ahead: ASCO 2024 Updates and Future Perspectives

EP: 13.Key Takeaways and Clinical Pearls on the Treatment of R/R MM in the Era of Bispecifics

EP: 14.Bispecific Antibodies Are Taking the Multiple Myeloma World by Storm

Video content above is prompted by the following question(s):

  • Focusing on recent approvals in earlier lines of therapy in relapsed/refractory multiple myeloma, discuss the CARTITUDE-4 and KarMMa-3 studies.
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4 experts in this video
4 experts in this video
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Developers designed cemsidomide as an orally bioavailable small molecule degrader that targets IKZF1/3, which drive multiple myeloma and non-Hodgkin lymphoma.

Cemsidomide Combo May Produce Responses in Multiple Myeloma

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May 8th 2025
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Investigators of the phase 1/2 CFT7455-1101 study have determined cemsidomide at a dose of 100 µg safe for expansion.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma

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October 14th 2024
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Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.


"[O]ur analysis supports the clinical efficacy and safety of IsaKd as a first-salvage therapy in a specific, and still existing, subset of [patients with multiple myeloma] who relapse during lenalidomide maintenance following autologous stem cell transplantation," according to the study authors.

Salvage Isatuximab Combo Elicits Efficacy in Lenalidomide-Relapsed Myeloma

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May 3rd 2025
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Extramedullary disease was the only factor that correlated with worse progression-free survival per multivariate analysis.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

Exploring the Potential Role of JAK Inhibitors in Multiple Myeloma

James R. Berenson, MD, FACP
September 30th 2024
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James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


“These findings highlight the critical need to address PEM in the management of [patients with multiple myeloma] with ACHF to mitigate the associated poor clinical outcomes,” according to the study authors.

Mortality, Adverse Outcome Odds Higher in Multiple Myeloma PEM Population

Russ Conroy
April 28th 2025
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Findings indicate a need to address protein-energy malnutrition in the treatment of those who have multiple myeloma with acute congestive heart failure.


Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

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April 27th 2025
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Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

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Developers designed cemsidomide as an orally bioavailable small molecule degrader that targets IKZF1/3, which drive multiple myeloma and non-Hodgkin lymphoma.

Cemsidomide Combo May Produce Responses in Multiple Myeloma

Russ Conroy
May 8th 2025
Article

Investigators of the phase 1/2 CFT7455-1101 study have determined cemsidomide at a dose of 100 µg safe for expansion.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma

Samantha Shenoy, NP, MSN
October 14th 2024
Podcast

Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.


"[O]ur analysis supports the clinical efficacy and safety of IsaKd as a first-salvage therapy in a specific, and still existing, subset of [patients with multiple myeloma] who relapse during lenalidomide maintenance following autologous stem cell transplantation," according to the study authors.

Salvage Isatuximab Combo Elicits Efficacy in Lenalidomide-Relapsed Myeloma

Russ Conroy
May 3rd 2025
Article

Extramedullary disease was the only factor that correlated with worse progression-free survival per multivariate analysis.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

Exploring the Potential Role of JAK Inhibitors in Multiple Myeloma

James R. Berenson, MD, FACP
September 30th 2024
Podcast

James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


“These findings highlight the critical need to address PEM in the management of [patients with multiple myeloma] with ACHF to mitigate the associated poor clinical outcomes,” according to the study authors.

Mortality, Adverse Outcome Odds Higher in Multiple Myeloma PEM Population

Russ Conroy
April 28th 2025
Article

Findings indicate a need to address protein-energy malnutrition in the treatment of those who have multiple myeloma with acute congestive heart failure.


Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

Roman Fabbricatore
April 27th 2025
Article

Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

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