Considerations in Sequencing BCMA-Targeting Bispecifics and CAR-T Therapies in R/R MM

Opinion
Video

Myeloma specialists discuss considerations they consider when determining how they sequence CAR T-cell therapies and bispecific antibodies.

Video content above is prompted by the following questions:

  • Can BCMA-targeting bispecifics be used in patients who have received prior BCMA-targeting CAR-T therapies?
    • Might you consider a different target?
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4 experts in this video
4 experts in this video
4 experts in this video
4 experts in this video
Andrezj Jakubowiak, MD, PhD, prioritizes KRd-based regimens for the treatment of high-risk newly diagnosed disease in the post-transplant setting.
Although a similar proportion achieved MRD negativity at the 10 to the –6 power, not enough studies have analyzed MRD at this level for multiple myeloma.
Unique toxicities presented with talquetamab tend to get progressively better as the treatment course continues, according to Prerna Mewawalla, MD.
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