Neal D. Shore, MD, on the Importance of Multidisciplinary Care in Advanced Prostate Cancer

Video

Neal D. Shore, MD, FACS, discusses the importance of multidisciplinary care for patients with advanced prostate cancer.

At the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, CancerNetwork® spoke with Neal D. Shore, MD, FACS, regarding the importance of multidisciplinary care for patients with advanced prostate cancer.

Incorporating a multidisciplinary approach for patients with advanced prostate cancer is essential in order to provide patients with further therapeutic benefit and improve quality of life.

Transcript:

When we are taking care of our patients with advanced cancers, and advanced prostate cancer is no exception, fatigue and the spectrum of neurocognitive maladies, as well as cardio-oncologic maladies become that much more important. All across the field of cancer in its totality, [we] are recognizing this. [By] incorporating a multidisciplinary approach, either as the [urologic] oncologist, the medical oncologist, the radiation oncologist, the nuclear medicine radiologist, or the pathologist—whoever is really involved in the care of the patient—appreciating that the spectrum of cardio-oncologic and neuro-oncologic differences in drugs of the same therapeutic class need to be studied [is important]. It may not affect all patients, it may not affect most patients, but there [are] clearly going to be certain patients or a significant population of patients [for whom] the right drug selection and comparable therapeutic mechanism of action classes could really benefit a patient and help their quality of life.

Recent Videos
Although accuracy remains a focus in whole-body MRI testing in patients with Li-Fraumeni syndrome, comfortable testing experiences may ease anxiety.
Subsequent testing among patients in a prospective study may affirm the ability of cfDNA sequencing to detect cancers in those with Li-Fraumeni syndrome.
cfDNA sequencing may allow for more accessible, frequent, and sensitive testing compared with standard surveillance in Li-Fraumeni syndrome.
STX-478 showed efficacy in patients with advanced solid tumors regardless of whether they had kinase domain or helical PI3K mutations.
STX-478 may avoid adverse effects associated with prior PI3K inhibitors that lack selectivity for the mutated protein vs the wild-type protein.
Phase 1 data may show the possibility of rationally designing agents that can preferentially target PI3K mutations in solid tumors.
Funding a clinical trial to further assess liquid biopsy in patients with Li-Fraumeni syndrome may help with detecting cancers early across the board.
Michael J. Hall, MD, MS, FASCO, discusses the need to reduce barriers to care for those with Li-Fraumeni syndrome, including those who live in rural areas.
Patrick Oh, MD, highlights next steps for further research in treating patients with systemic therapy in addition to radiotherapy for early-stage NSCLC.
The ability of metformin to disrupt mitochondrial metabolism may help mitigate the risk of cancer in patients with Li-Fraumeni syndrome.
Related Content